In general, systems and methods for monitoring and communicating information using drug administration devices are provided.

A droplet delivery device and related methods for delivering a low surface tension composition as a stream of droplets to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The ejector mechanism includes a piezoelectric actuator and an aperture plate, the aperture plate having a plurality of openings formed through its thickness, and one or more surfaces configured to provide a desired surface contact angle, and the piezoelectric actuator operable to oscillate the aperture plate at a frequency to thereby generate the ejected stream of droplets.

A device, system and method related to a pneumatic system for fluid analysis. The device, system and method comprises a connection interface for a fluid analyser unit, a connection interface for a pump unit, a flow sensor and a pressure sensor. The device, system and method further comprises a control unit for calculating a pump stroke force or amplitude, and/or pump frequency based on measurements from the flow sensor and the pressure sensor for obtaining a constant flow through the pneumatic system.

A ventilator system, comprising: an inhalation pathway comprising an ambient air inlet, a bi-directional emergency valve, and a dynamic blower; and an exhalation pathway comprising a bi-directional exhalation valve and an exhalation port; wherein when a blockage occurs in the inhalation pathway, ambient air can be drawn from the exhalation port and through the bi-directional exhalation valve, and during exhalation exhalant exits the ventilator through the bi-directional exhalation valve and the exhalation port; wherein when a blockage occurs in the exhalation pathway, inhalant is delivered by the dynamic blower, and during exhalation the dynamic blower lowers its speed or stops and the exhalant exits the ventilator through the bi-directional emergency valve, the dynamic blower, and the ambient air inlet.

A process for monitoring a measuring system (110) for mechanical ventilation of a patient (20) is carried out while a fluid connection (40) is established between the patient (20) and a medical device (100). A gas sample is suctioned from the fluid connection (40) and is sent through a gas sensor fluid-guiding unit (52) to a gas sensor array (50). A time curve of the CO2 concentration and O2 concentration in the suctioned gas sample are determined. A concentration change curve of the change over time of the CO2 concentration and the O2 concentration are calculated. A search is made for a time period in which the two concentration change curves continuously have the same sign. Upon detecting such a time period it is checked whether a predefined first leak criterion is met. When this is the case, an indication of a leak (L) is detected.

A computer-implemented method for using a sensor incorporated into a mask, computer program product, and mask with a computer system for obtaining, from a sensor, data associated with a biological attribute of a user. The data may be processed to determine whether the data is within a threshold range. An indication of whether the data is within the threshold range may be provided.

A ventilator is provided that dynamical adjusts the pressure, flow, and volume of the delivered gas to a patient as the condition of the patient changes. The ventilator adjusts the flow and mixing of gases through flow control valves. The ventilator includes at least two banks of valves, each bank having a plurality of valves, where each valve in the bank has a specific orifice size that is different from at least one other valve in the respective bank of valves. In one example, the ventilator further includes an exhalation valve assembly having an exhalation valve housing and exhalation valve base coupled together to retain a flexible exhalation tube. The exhalation valve assembly including at least two pistons extending at least partially through the exhalation valve assembly to contact the exhalation tube and, when actuated, impart pressure on the walls of flexible exhalation tube to restrict or completely close the flow of air through the flexible exhalation tube.

An inhaler that includes a housing having a body configured to receive an active substance container containing an active substance, and an air channel extending within the housing; an administration element for nebulising or vaporising the active substance for mixing the active substance with air flowing in the air channel; an electronic control apparatus; an electronic data storage device; and a sensor system having a flow measuring apparatus for measuring a volume flow and a mass flow of the air and the active substance for storage as active substance delivery data; wherein: the electronic control apparatus is configured to convert active substance administration data into administration data to control the mixing of the active substance with the air; and the electronic control apparatus is configured to calculate a quantity of the active substance delivered from the active substance container and to compare the quantity with the active substance administration data.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

A mechanical insufflation-exsufflation device including an air source to provide positive airway pressure (PAP); a patient interface; at least one sensor to sense air pressure and flow at the patient interface; and a controller to control the air source to deliver at least one mechanically assisted cough to the patient in response to at least one of a target breathing flow and a target inhalation time period being sensed by the at least one sensor, and when the at least one of a target breathing flow and a target inhalation time period is not sensed, the controller is configured to control the air source to deliver each in a series of high-level PAP provided over a duration being followed by a low-level PAP provided over a duration, the series of high-level PAP increasing in pressure level and duration from a prior one in the series of high-level PAP.