A method and circuit are provided for implementing an enhanced bias configuration for CMOS inverter based optical Transimpedance Amplifiers (TIAs). An operational amplifier is provided in a feedback configuration that forces an input of the CMOS inverter to a set voltage level by regulation of the inverter power supply. A photo-detector sees a more stable bias voltage, and the responsivity of the photo-detector is more robust and the TIA has improved performance across process corners.