A sleep apnea syndrome symptom improvement aid 1 includes a sandwiching target 10 sandwiched by front teeth of a patient, a tongue presser 20 extending from the sandwiching target 10 to the vicinity of the soft palate of the patient and including an elastic body configured to press the tongue, and a detector 30 configured to detect at least one of a vital sign or a salivary component of the patient.

A sublingual delivery device, system and method of operating such are provided. The sublingual delivery device comprises a device body comprising a delivery button configured to operate the sublingual delivery device, an ampoule carrying liquid, a threaded rod configured to push the ampoule towards a proximal end of the device body, a joints mechanism configured to convert vertical motion of the delivery button to horizontal motion of the threaded rod, an adjustment knob configured to set the volume of liquid to be delivered by adjusting a rotation degree of the knob, the knob located at a distal end of the device body, and a mouthpiece configured to be placed into a mouth of a user, the mouthpiece located at the proximal end of the device body, and the mouthpiece comprising a hollow needle configured to penetrate the ampoule and deliver liquid from the ampoule into the mouth of the user.

A tongue attachment assembly includes a sheath designed for attachment to a patient's tongue using a vacuum. An accessory attachment feature comprising a groove located between a flange and the distal end of the body of the sheath. Vacuum can be drawn through a valve or an external vacuum source. The tongue attachment assembly can be adapted for any of a variety of applications by selecting an appropriate accessory and attaching the accessory to the sheath by the accessory attachment feature. Accessories can include a sleep apnea attachment, a gas delivery mask retention attachment, and the like. A tongue shape restoration device can be employed to restore the tongue from a shape that is deformed by the tongue attachment assembly to a natural shape. The tongue shape restoration device can be a pair of cantilevered arms, an orbital shaped device, or any other suitable component.

A portable, self-contained vacuum tongue cleaning device uses a removable cleaning head so that different heads can be used with different users. The device includes a debris and saliva separator that removes the debris and saliva from the vacuum flow. This separator is carried by the cleaning head in order to minimize required cleaning of the base of the device. The base carries a vacuum pump, a power supply, a switch, and an inlet that allows the power supply to be recharged. The device is configured for emergency use in an oral surgeon's office wherein vacuum flow is required during surgeries.

An airway device to be inserted into a patient's throat and to be function as a supraglottic airway device during a positive pressure ventilation and spontaneous ventilation that includes an air tube, an air sac, a tongue lifting means, a pulling unit and a drainage systems. The pulling unit will be pulled by an operator's hand to cause the tongue lifting means upward movement to open up the air sac and lift up the tongue base. The air tube lumen and the air sac are configured to have inflow airflow be divided and follow specific route therefore to deliver the focused airflow to vocal cords opening, and also to let inspired airflow enter desired area of the air sac to expand the air sac to form seals with surrounding tissue. During expiration, the pressure will be relieved. Different design of the drainage system can be configured to drained fluid from upper esophagus or from posterior pharyngeal wall.

The present invention relates to pharmaceutical compositions of ramelteon and methods of use thereof. More specifically, the present invention relates to pharmaceutical compositions of ramelteon for use in the treatment of insomnia and jet lag by transmucosal administration. The present invention achieved faster onset of pharmacological effects by delivery of low dosage of ramelteon via intranasal or sublingual routes, as compared to conventional oral tablet administration.

A method of reducing anxiety in a subject. In some embodiments, the method includes the steps of: providing an audio input to the subject, the audio input including a sequence of tones in a frequency range comprising about 100 Hz to about 8000 Hz and having intensities adapted to audiometric parameters of the subject; producing a plurality of actuation signals correlated with the audio input; delivering an actuation signal of the plurality of actuation signals to each of a plurality of electrodes in contact with a tissue surface of the subject's body to provide tactile stimuli to the tissue surface; and reducing anxiety in the subject.

A device for alleviating obstructive sleep apnea, comprising: a base fitted and fixed to an user's head and having a passage portion; an adjustment element extending into the passage portion and undergoing relative displacement therein; a locking element disposed at the passage portion, wherein an user uses the locking element to fix the adjustment element in place to limit the relative displacement of the adjustment element; a suction member undergoing relative displacement relative to the passage portion together with the adjustment element and having a channel, wherein the channel extends into the adjustment element, undergoes relative displacement in the adjustment element, and connects to a tongue fixing portion disposed at the front end of the user's tongue; and a negative pressure source being mounted on the base and in communication with the channel, providing a negative pressure to the user's tongue in contact with the tongue fixing portion.

A method and system for modulating a patient's responses to a medical intervention is provided. The method comprises provisioning a system with immersive content comprising visual content and associating at least one stimulation with the visual content, wherein the stimulation is selected from the group consisting of auditory stimulations, olfactory stimulations, gustatory stimulations, neurological stimulations, environmental stimulations, and tactile stimulations; allowing for the selection of an immersive experience from the immersive content; and responsive to said selection, rendering the immersive experience to the user by providing visual content to the user via a display device, and performing at least one stimulation associated with the visual content.

A method of ameliorating a migraine utilizing a frozen caffeinated comestible, the method constituted of: a) abutting a portion of the frozen caffeinated comestible to a user palate for at least 5 seconds; b) detaching the abutted portion from the user palate for a detachment period; and c) continuously repeating steps a-b until at least 70 milligrams of caffeine from the frozen caffeinated comestible have been consumed over a total period of at least 4 minutes.