Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Miniaturized high-intensity shortwave UV airflow treatment system in a compact easy-to-wear and fully portable form factor. Practical, germicidal air treatment system may be worn by or be carried by a user to kill or deactivate germs, viruses or other pathogens, which are located in the air to be breathed by the user. Air being inhaled or exhaled by the user is exposed to Ultra-Violet C-band (UVC) radiation. This UVC radiation is lethal to undesirable germs, viruses and other pathogens. In this manner, pathogen-free air is being inhaled or exhaled by the user.

A medication delivery apparatus and system for the application of a medical agent to a treatment site, such as an airway, and method for use of same are disclosed. In one embodiment of the medication delivery apparatus and system, a reservoir supplies a medical agent to a lower chamber of a housing wherein an ultrasonic transducer applies ultrasonic energy thereto, thereby nebulizing the medical agent. A control valve is interposed between a source of positive pressure air and an upper chamber of the housing to selectively apply positive air pressure to the upper chamber. Upon the application of positive air pressure, the airflow delivers the nebulized medical agent to a target location, such as the airway.

A medication delivery apparatus and system for the application of a local anesthetic to a treatment site, such as an airway, and method for use of same are disclosed. In one embodiment of the medication delivery apparatus and system, a reservoir supplies a local anesthetic to a lower chamber of a housing wherein an ultrasonic transducer applies ultrasonic energy thereto, thereby nebulizing the local anesthetic. A control valve is interposed between a source of positive pressure air and an upper chamber of the housing to selectively apply positive air pressure to the upper chamber. Upon the application of positive air pressure, the airflow delivers the nebulized anesthetic to a patient's airway by way of a laryngoscope side port coupling, laryngoscope vacuum port coupling, or catheter coupling, for example. The application of local anesthetic, itself, in this nebulized manner mitigates gaging, chocking, aspirating, bucking and laryngospasms.

A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a primal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distill ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides.

An intubation assistance device facilitates insertion of an endotracheal tube or a guide wire into a patient's trachea without requiring a laryngoscope. The device includes a curved flexible tubular member that has a proximal portion having a proximal end, a distal portion having a distal end, and a curved portion between the proximal portion and the distal portion. A lumen extends from the proximal end of the tubular member and terminates in the curved portion of the tubular member. The lumen is sized and shaped so that an endotracheal tube and/or a guide wire is axially moveable through the lumen. A ramp is disposed at a distal end of the lumen, and is angled to facilitate insertion of the endotracheal tube and/or guide wire into the patient's trachea. The distal portion of the tubular member includes an esophageal protrusion that is configured to be inserted in the patient's esophagus.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

To more easily perform sputum suctioning at a low degree of invasion. An aspirate-guiding apparatus for guiding an aspirate from a living body to an upper respiratory tract includes an aspirate outlet through which the aspirate is dischargeable, a patient connection port that is connectable to a patient, an intake port that is connectable to an intake apparatus, and a switching valve that switches a connection source of the patient connection port to the aspirate outlet or the intake port. The aspirate-guiding apparatus further includes a casing that includes the aspirate outlet, the patient connection port, and the intake port. The switching valve is slidably provided in the casing and is capable of switching the connection source of the patient connection port to the aspirate outlet or the intake port.