Disclosed herein, in some aspects, are endotracheal stimulation platforms, systems, and methods of their use for pacing the phrenic nerves, right and/or left phrenic nerves, of a subject. In some embodiments, one or more pairs of electrodes are provided through an ET tube to contact a portion of a tracheal wall, or trachea, so as to enable phrenic nerve pacing. In some cases, the one or more pairs of electrodes are configured to send electrical pulses that stimulate the phrenic nerve, thereby helping promote contraction and relaxation of the diaphragm muscle.

An intubation system of the present disclosure intubates based on an airway pattern indicating a trachea opening. The airway pattern is determined from analysis of airway data detected by a trachea identifying device disposed on a moveable guide stylet of the intubation system. A navigation element is generated based on the airway pattern. In one embodiment, the airway pattern is a gas exchange pattern indicating a trachea opening. In another embodiment, the trachea opening transition pattern is a topographic pattern indicating a trachea opening. The guide stylet is capable of moving in a plurality of degrees of freedom in the airway following the guidance from the navigation element.

A medicine administering device for delivering anesthetizing fluid on trachea is disclosed. The medicine administering device includes a syringe and a cannula. The cannula extends from the syringe. The cannula is made of a low-density polyethylene with malleable properties such that the cannula can bend and flex without breaking during use. Further, the cannula has a bendable portion with axial holes towards its distal end. The medicine administering device includes a medicine container. The medicine container contains anesthetizing fluid. The syringe receives the medicine container. A doctor places the cannula in the airway of a patient and operates the syringe to expel a predetermined volume of the anesthetizing fluid from the medicine container. The anesthetizing fluid flows through the cannula and gets sprayed from the axial holes onto the trachea.

The invention relates to a device for immobilizing oxygen-administering tubes in anaesthetized patients, where the corresponding endotracheal tube comprises, on the distal end thereof, a balloon or bag to be placed in the branch of the trachea of the patient, characterised in that a pair of balloons or bags are connected to the endotracheal tube itself, one of them having an omega shape, and the other being spherical and larger, and both being arranged inside the mouth of the patient and being associated with respective valves for the inflation thereof.

A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a proximal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distal ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Implants comprising electrically-responsive hydrogel are described. Systems to provide electricity to induce response in hydrogel-containing implants are described. Methods for utilizing said system and methods for utilizing said hydrogel-containing implants are described.

Disclosed herein are endotracheal tubes that have multiple inflatable cuffs to help form a seal for ventilation, to reduce unwanted migration of the tube relative to the patient, reduce focalized pressure from a single cuff, and to help prevent aspiration of materials between the outside of the tube and the tracheal walls. Some devices include first and second distal cuffs for placement within the trachea and a proximal third cuff for blocking the entrance to the trachea. The cuffs can include ridges or textures to enhance sealing. The device can also include inflation channels, vacuum channels, and pressure sensors.

Some implementations of the disclosure are directed to a balloon dilator system, including: a balloon pump hand piece configured to pump pressurized fluid through a flexible tube to inflate an inflatable balloon, the balloon pump hand piece comprising: an attachment mechanism for removably coupling the balloon pump hand piece to a proximal end of an endoscope; the flexible tube, wherein the flexible tube is configured to be in fluid communication with the balloon pump hand piece at a first end of the flexible tube, and the inflatable balloon at a second end of the flexible tube; a hollow inner cannula; and the inflatable balloon, wherein the inflatable balloon is external to and circumferentially attached to the hollow inner cannula between the proximal end of the hollow inner cannula and the distal end of the hollow inner cannula.

A tracheal administering device for an active substance comprises an endotracheal tube with a ventilation lumen which extends therein to carry a respiratory airflow. A liquid conduit connects with a proximal part to a liquid system for delivering a liquid with the active substance under an increased operating pressure. A distal part of the liquid conduit is coupled to a spraying device, comprising a ceramic spray plate with at least one spray channel. The spray channel has a cross-section smaller than about five micrometres, and receives the liquid on an inlet side of the liquid conduit and delivers therefrom at least one mist jet to the respiratory gas flow. The mist jet comprises a series of droplets of at least substantially the same size into which the liquid has been scattered as a result of Rayleigh instability, this size being at most twice to three times the stated cross-section of the spray channel.