A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a proximal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distal ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides.

An embodiment of a system for treating sleep apnea includes a collar, a pump, and a motor. The collar has a vacuum surface and has a sealing surface that is configured to form a seal with a region of a neck of a subject having an airway. The pump is secured to the collar, and is configured to maintain the airway open by drawing a vacuum between the vacuum surface of the collar and a region of a throat of the subject. And the motor is secured to the collar and is configured to drive the pump. As compared to existing systems (e.g., a Continuous Positive Airway Pressure (CPAP) system) for treating sleep apnea, the above-described system may be more portable, more comfortable, may be less likely to require adjustment while a subject using the system is asleep, and, therefore, may be less likely to awaken the subject.

A medical elongated body including a catheter main body. The catheter main body has a tubular body and a lumen. The tubular body includes a guide wire lumen into which a guide wire is insertable. The tubular body also a distal member positioned at the distal portion of the tubular body. The distal member has a lumen that communicates with the guide wire lumen. The inner diameter of the distal member decreases between the proximal end and a distal end opening of the distal member. The medical elongated body also includes a visible marker that extends circumferentially on the outer surface of the distal member to indicate a position of the distal member in the axial direction corresponding to a predetermined inner diameter of the distal member. The visible marker is visible before the medical elongated body is inserted into a living body.

An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.

An embodiment of a system for treating sleep apnea includes a collar, a pump, a motor, a sensor, and a controller. The collar is configured to maintain an airway of a subject open while the subject is sleeping by applying, to a throat of the subject, a negative pressure having a magnitude, and the pump is configured to generate the negative pressure. The motor is configured to drive the pump, and the sensor is configured to generate a sense signal that is related to a degree to which the airway is open. And the controller is configured to vary the magnitude of the negative pressure in response to the sense signal. For example, one or more of the pump, motor, sensor, and controller can be secured to the collar such that the system is self-contained, i.e., the entire sleep-apnea system can be worn by the subject.

An intubation device is provided. An intubation device comprises a movable guide configured to guide an insertion of an endotracheal tube into a trachea of a patient, the guide having a guide extension and a guide tip; an external trachea identifier source external to the trachea and disposed on the patient during an intubation, wherein the trachea identifier source generates and transmits a signal; at least one trachea condition sensor disposed on the guide tip to detect the signal generated by the trachea identifier source; and a guide control device operatively coupled to the guide, the guide control device configured to move the guide into the trachea in response to the detected signal.

A device for introducing a material into a body cavity is shown. The device includes a catheter with a distal tip. A first lumen extends through the catheter. The catheter is configured to form a mist from liquid passed through the first lumen, for example including a misting nozzle in fluid communication with the first lumen and configured to provide a mist from a flow of liquid through the first lumen. An inflatable balloon may be included on the catheter to allow the user to isolate the portion of the body in which the material is introduced. Additional described features can provide for controlled deflection of a distal region of the catheter, guidewire or guide loop tool lumens, first and second misting nozzles on the catheter, and delivery apparatuses including the catheter devices coupled or that can be coupled to endoscopes such as bronchoscopes. Methods of use of the catheter devices and delivery apparatuses are also described.

A catheter for tracheal or bronchial suction including a unit for displaying the artificial airways, the trachea and the bronchial tree so as to allow the removal of secretions; in particular, the catheter for tracheal or bronchial suction includes optical fibers, a microcamera or another visualization technology positioned in the distal end. The operator can identify the position of the distal end, of the artificial airways, of the trachea and of the bronchial tree on the screen. Therefore it is possible to ensure that the tube of the catheter is adjacent to or inside collections of fluid secretions or other material to be sucked up. The suction can be selectively applied to avoid damage to the mucosa and to facilitate the more complete elimination of secretions.

The invention provides devices and systems that help deliver agents of interest, such as therapeutic agents (e.g., nucleic acid vectors) to cells of hollow tissues, such as lung. Also provided herein are methods of using such devices, including methods of treating diseases by delivering therapeutic agents to hollow tissues.

A method for treating esophageal cancer in situ with heated air that can be inhaled through a face mask, at an elevated temperature less than sauna air temperatures and at a constant positive air pressure. The inhaled heated air will heat the very thin tracheoesophageal party wall sheath membrane between the esophagus and the respiratory trachea in the throat. The tracheoesophageal party wall sheath membrane therefore can heat the esophageal cancer tumor adjacent to the heated trachea and tracheoesophageal party wall sheath membrane. The heated air will be inspired/inhaled through the mouth and into the trachea/windpipe. Then the trachea and trachea tube under heated constant positive pressure will then transfer heat through and to the esophagus wall, and esophagus and tumor. The heat from the heater air inspiration through the trachea migrates/transmits/disperses across the membrane separating the trachea/windpipe from the esophagus and hits the esophagus with heat.