A system and method for performing a bronchoscopy. The system may include a bronchoscope, a multi-fluid conduit apparatus, and a switching apparatus. The bronchoscope may include an insertion tube having a distal end, a control section, and a working channel. The multi-fluid conduit apparatus may include a first conduit section operably coupled to a vacuum source, a second conduit section operably coupled to an oxygen source, and a third conduit section operably coupled to the working channel, each of the first and second conduit sections being fluidly coupled to the third conduit section. The switching apparatus may include a valve apparatus operably coupled to each of the first and second conduit sections and an actuator apparatus operably coupled to the valve apparatus. The actuator apparatus may alter the valve apparatus between: (1) a suction supply state; and (2) an oxygen supply state.

Embodiments are directed to an endotracheal intubation system that provides for differential ventilation of lungs and lung lobes.

The present technology relates to a catheter navigation system that includes a catheter comprising a steerable distal tip including a proximity sensor. The system also includes a catheter controller. The catheter controller includes a processor; and memory storing instructions that, when executed by the processor, cause the catheter controller to perform operations. The operations may include receiving, from the catheter, a proximity signal generated by the proximity sensor, identifying a steering target based on the proximity signal, and generating a steering signal to steer the steerable distal tip towards the steering target.

A tracheal tube can be easily positioned and has no risk of unexpectedly blocking a bronchus. This tracheal tube is inserted through the trachea and a bronchus of a subject, and includes: a tube body which has a through hole formed on the outer peripheral surface; and bronchus cuffs which are formed on the outer peripheral surface of the tube body and which press the inner peripheral surface of the bronchus. The bronchus cuffs are formed spaced apart in the axial direction of the tube body and form a plurality of vent spaces which communicate with each other. The through hole communicates with the vent spaces.

We describe a Tracheal Tube insertion facilitator (modified bougie) with superior ventilating capability to enable medical/paramedical personnel to place tracheal/bronchial tubes reliably in trachea/bronchus of the patients under anaesthesia or patients in respiratory distress, and provide respiratory support. This device is particularly useful in situations where the conventional tracheal intubation technique using a laryngoscope is difficult or near impossible. This device has a outer cylindrical member, inner hollow stylet and a dynamic cuff which inflates during Positive Pressure Ventilation/Jet ventilation, and hence enabling oxygenation in patients with respiratory distress even before the tracheal tube is inserted into the patient's airway.

A bronchoscopy scope guide (30) for a non-invasive ventilation (NIV) patient interface (10) comprises a semi-rigid scope guide tube (32), a bronchoscopy scope seal (48), and a semi-rigid grommet (34). The semi-rigid scope guide tube (32) includes a principal axis (36) and entrance and exit guide portions (38,40). The bronchoscopy scope seal (48) couples to the scope guide tube for sealing around a bronchoscopy scope when inserted through the scope guide tube. The semi-rigid grommet (34) is disposed about an outer circumference of and flexibly coupled to the scope guide tube (32) and is located in a principal plane (52) transverse to the principal axis of the scope guide tube. The scope guide tube (32) is pivotally manipulate-able about the flexible coupling of the grommet (34) for positioning a distal end (46) of the exit guide portion of the scope guide tube proximate, but not in contact with, one of a nasal cavity or mouth opening of a patient for assisted guidance control of the bronchoscopy scope within an interior region (58) of the patient interface (10) in performance of a bronchoscopy procedure.

A bronchoscopy scope guide (30) for a non-invasive ventilation (NIV) patient interface (10) comprises a semi-rigid scope guide tube (32), a bronchoscopy scope seal (48), and a semi-rigid grommet (34). The semi-rigid scope guide tube (32) includes a principal axis (36) and entrance and exit guide portions (38,40). The bronchoscopy scope seal (48) couples to the scope guide tube for sealing around a bronchoscopy scope when inserted through the scope guide tube. The semi-rigid grommet (34) is disposed about an outer circumference of and flexibly coupled to the scope guide tube (32) and is located in a principal plane (52) transverse to the principal axis of the scope guide tube. The scope guide tube (32) is pivotally manipulate-able about the flexible coupling of the grommet (34) for positioning a distal end (46) of the exit guide portion of the scope guide tube proximate, but not in contact with, one of a nasal cavity or mouth opening of a patient for assisted guidance control of the bronchoscopy scope within an interior region (58) of the patient interface (10) in performance of a bronchoscopy procedure.

Systems and methods for the delivery of devices such as films to target locations in mammalian bodies are provided herein. The films may be configured to release a therapeutic agent over time, among other features. Delivery devices and methods described herein may be particularly well-suited for the delivery of therapeutic films to a target location in the sinuses.

Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Apparatus for providing intrabronchial delivery of neurotoxins to control the effects of asthma comprises a shaft having proximal and distal ends and a neurotoxin applicator assembly disposed on the distal end. The neurotoxin applicator assembly comprises a deployable needle assembly, a rotating needle assembly, and a needle-less injection assembly or a nebulizer assembly.