A catheter includes a shaft portion defining a non-circular transverse cross-section. The shaft portion includes an exterior sidewall and an interior sidewall defining two or more asymmetrical working channels.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.

A system and method enabling the receipt of image data of a patient, identification of one or more locations within the image data depicting symptoms of lung disease, analyzing airways and vasculature proximate the identified locations, planning a pathway to the one or more locations, navigating an extended working channel to one of the locations, identifying the direction of blood flow within vasculature serving the location, positioning a catheter proximate the location, and temporarily isolating a portion of the identified vasculature serving the location depicting symptoms of lung disease.

A treatment system includes a guide sheath, and a catheter provided with a pressure-controlled element. The pressure-control element preferably includes an expanded configuration adapted to extend across a small feeder vessel branching from the splenic vein. The pressure-control element is positioned with the feeder vessel, and a therapeutic agent is delivered under pressure directly into the feeder vessel, where it is forced to penetrate deep into tissue. Pressure responsive elements for monitoring intravascular pressure are also provided to time delivery of the therapeutic agent for maximum uptake by the target organ. Methods for treating tissues and organs via vascular pathways are provided.

A method for delivery of one or more active agents into the pulmonary system of a subject using liquid foam is provided. The invention further provides a pulmonary drug delivery device for providing a liquid foam to a target site of a respiratory system.

Disclosed embodiments include flexible tube assemblies, flexible needle assemblies, systems, methods of fabricating a flexible tube, and methods of fabricating a flexible needle. In an illustrative, non-limiting embodiment, a flexible tube assembly includes: a flexible tube having a proximal end with a proximal strain relief section and a distal end with a distal strain relief section, the proximal strain relief section being located between the proximal end and the distal strain relief section and the distal strain relief section being located between the distal end and the proximal strain relief section, the distal end defining an opening therein, at least a portion of at least one of the proximal strain relief section and the distal strain relief section defining therein a spiral cut with a continuously variable pitch; and tubing disposed in an airtight manner over an exterior surface of the flexible tube at least the portion of the at least one of the proximal strain relief section and the distal strain relief section defining therein the spiral cut with a continuously variable pitch.

Methods and devices for diagnosing, monitoring, and/or treating tissue through an opening or port through an airway wall. A passageway is created extending from the airway to the target tissue. The passageway provides local access to the target tissue for treatment instruments and for delivering agents.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

To reduce the suffering of the patient and enable easier removal of excess fluid such as pleural effusion fluid from the chest space, the disclosure provides a catheter for chest drainage intended for removal of excess fluid from a chest space of a living body and to be placed in the living body in such a manner as to extend from an inside of the chest space to an outside of the living body. The catheter includes a passage member formed of a flexible sheet and having a passage through which the excess fluid is to be drained, and an indwelling member formed of an elastic body and provided at a proximal end of the passage member. The indwelling member has an inlet that allows the excess fluid to flow through. The indwelling member includes a retaining portion spreading in a flange shape and being retainable at a chest wall.