A catheter, a guide wire, an opening position identification device, an opening position identification method, an internal object presence determination assistance device, a diagnostic assistance device, and a treatment assistance device that can easily identify the position of an opening of the catheter in a body are provided. A guide wire 20 is inserted into a catheter 30 having openings for introducing a fluid substance into the body, or for sucking the fluid substance in the body. One or more light sources 10 for identifying the positions of openings 32 of the catheter 30 are provided. The catheter 30 may be provided with one or more light sources 10 for identifying the positions of the openings 32 of the catheter 30.

Devices, systems and methods for localized delivery of a fluid therapy to a target tissue area of an internal body organ of a patient. A catheter forms a sealed treatment chamber in a natural lumen extending through the target tissue area. A fluid solution fills the treatment chamber for an adequate treatment session time, solution volume and/or drug concentration thereby providing the treatment. The fluid solution may be circulated or recirculated through the chamber or maintained stationary therewithin to treat the organ.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

A fluid delivery and airway management device including a tubular member dimensioned for introducing a fluid into a trachea of a mammal, the tubular member having a proximal portion, a distal portion, and a middle portion between the proximal portion and the distal portion. The tubular member is dimensioned for positioning of the proximal portion in an oral cavity of a mammal, the middle portion in an oropharynx of the mammal and the distal portion in an esophagus of the mammal. An inflatable oral cavity balloon is positioned at the proximal portion and dimensioned to occlude the oral cavity. An inflatable esophageal balloon is positioned at the distal portion and dimensioned to occlude the esophagus. Apertures may be formed within the middle portion such that a fluid introduced into the tubular member is output through the apertures to a trachea.

A medical system for assisting with an intubation procedure for a patient. The system comprising airflow sensors configured to obtain data indicative of airflow in the patient's airway and physiological sensors configured to obtain information regarding airflow in the patient's lungs. The system further including a monitoring device communicatively coupled to the airflow sensors and the physiological sensors. The patient monitoring device comprising at least one processor coupled to memory and configured to: provide a user interface on a display and assist the rescuer in determining proper placement of an endotracheal tube, receive the data indicative of the airflow in the patient's airway, receive the physiological information regarding the airflow in the patient's lungs, and determine whether the tube is properly placed based on the received physiological information, and present an output of the determination of whether the ET tube was properly placed.

Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

A system may comprise a flexible elongated device including a fluid channel and a pore extending between the fluid channel and a surface of the flexible elongated device and a lubricious layer extending over at least a portion of the surface of the flexible elongated device. The system may also comprise a fluid system coupled to the flexible elongated device and a control system configured to cause fluid to be released by the fluid system to the fluid channel of the flexible elongated device. The fluid in the fluid channel flows through the pore to transition the lubricious layer from a dehydrated condition to a hydrated condition.

A device may include a processor. The processor may be configured to receive data during a surgery. The processor may receive data representative of a patient's intraoperative air exchange. The data may represent air exchange for a patient's breath cycle. For example, data may include any of ventilator inlet flow rate, ventilator inlet pressure, ventilator output pressure, chest tube flow rate, or chest tube pressure. The processor may also receive data representative of a surgical parameter other than one related to air exchange. For example, this data may include any of patient medical record data, intraoperative reporting data, surgical procedure data, or the like. The processor may be configured to receive an updated machine learning model from a cloud resource. And the processor may output, during the surgery, information indicative of prolonged-air-leak-likelihood based on data.