The present disclosure relates generally to methods and apparatus to control delivery of a sealant during an invasive procedure. Disclosed methods and apparatus control movement of a syringe to control injection of sealant stored therein. For example, disclosed methods and apparatus can displace the syringe body relative to the plunger as the syringe is withdrawn from the target site, rather than displacing the plunger relative to the syringe body, to thereby pressurize the sealant or inject the sealant in an amount proportional to a distance the syringe body is withdrawn. This reduces the variability in the amount of sealant delivered along the syringe withdrawal pathway. The disclosed methods and apparatus can increase precision in movement of a syringe, thereby increasing precision in sealant delivery.

An apparatus includes a catheter, and an electrode and methods of delivering molecules to eukaryotic cells using such an apparatus. The catheter defines a fluidic channel and has a distal opening. The electrode is within the fluidic channel and is spaced a distance from the distal opening of the catheter. The catheter is arranged to prevent direct contact between any electrode of the apparatus and tissue. Related apparatus, systems, techniques and articles are also described.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

A lung isolation tube assembly including a control valve that is adapted to be moved between a left lumen position, a right lumen position, and a both lumens position, a connector that is in fluid communication with the control valve, and a tube that is in fluid communication with the connector. The tube includes a left lumen that is in fluid communication with the connector and a right lumen that is in fluid communication with the connector. The assembly also includes a first cuff that is disposed around a portion of the right lumen and the left lumen and a second cuff that is disposed around the left lumen. The assembly is adapted to convey airflow or oxygen to a human lung via at least one of the left lumen and the right lumen. A method for isolating a human lung.

A method to regulate patient gene expression by controllably circulating antisense oligonucleotide material (ASO) through a closed fluid circuit formed between the patient's ventricle and lumbar regions. To that end, after coupling a fluid channel between those regions, such embodiments add ASO to the fluid channel (preferably after the channel is primed with CSF) and energize a pump to controllably flow the CSF and the ASO mixed with the CSF. CSF/ASO fluid flow may be managed to localize treatment (e.g., providing deep brain distribution) while minimizing toxicity potentially caused by the ASO to certain nerves (e.g., the peripheral nerve).

A medical system for assisting with an intubation procedure for a patient. The system comprising airflow sensors configured to obtain data indicative of airflow in the patient's airway and physiological sensors configured to obtain information regarding airflow in the patient's lungs. The system further including a monitoring device communicatively coupled to the airflow sensors and the physiological sensors. The patient monitoring device comprising at least one processor coupled to memory and configured to: provide a user interface on a display and assist the rescuer in determining proper placement of an endotracheal tube, receive the data indicative of the airflow in the patient's airway, receive the physiological information regarding the airflow in the patient's lungs, and determine whether the tube is properly placed based on the received physiological information, and present an output of the determination of whether the ET tube was properly placed.

A ventilator (1), for ventilating the lungs of a patient with breathing air, includes a ventilation module (2) for generating a breathing air flow, a determination module (3) for determining a first ventilation parameter as well as a different second ventilation parameter of the ventilator, and a control module (4) for controlling the ventilator as a function of the determined first and/or second ventilation parameter. The control module is configured to reduce the first ventilation parameter automatically over an analysis period including at least one breathing cycle. A classification module (5) is configured to classify a pulmonary status of the lungs of the patient based on a change in the second ventilation parameter, which change was brought about by the automatic reduction of the first ventilation parameter. A process is further provided for ventilating the lungs of a patient with breathing air with a ventilator (1).

Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

A device and a process determine a value indicative of a respective regional compliance of lungs of a patient (P) in a plurality of different regions of the lungs. An airway pressure sensor (3) measures a value indicative of the pressure (Paw), which is variable over time, at the airway of the patient (P). A difference between the end-inspiratory transpulmonary pressure and the end-expiratory transpulmonary pressure is determined. An EIT measuring device (17) measures by electrical impedance tomography (EIT) a change in volume of a lung region. The difference between the end-inspiratory volume and the end-expiratory volume of the lung region is determined with the use of signals of the EIT measuring device (17). A quotient of the volume difference for the region in question and the pressure difference present at the lungs is calculated as the value indicative of the regional compliance of the lung region.

Methods and apparatus involve generation of an anti-infection therapy. The method/apparatus may include a controller controlling setting of a respiratory flow therapy device for the therapy. The controller may compute a target flow rate profile for a patient using a margin function, such that the target flow rate profile, according to the margin function, exceeds a minimum inspiratory flow rate profile of the patient's inspiration. The controller may control setting the respiratory flow therapy device to generate a flow of air to a patient interface according to the target flow rate profile, where the generation may be in synchrony with a sensed parameter that is indicative of a breathing cycle of the patient.