Renal and urine collection system interventions are provided that improve kidney function by manipulating pressures and/or infusing therapeutic agents in the renal pelvis of the kidney or kidneys. Setting a vacuum and/or infusing therapeutic agents in the renal pelvis results in increased glomerular filtration rate, general solute clearance, and free water excretion via the kidney through the urinary tract and is useful for treatment of CHF, ADHF, AKI, CKD, and many other conditions characterized by fluid overload by reducing fluid buildup. The fluid drawn from the renal pelvis or pelvises is delivered to an external or implanted reservoir or to the bladder using flow manipulation mechanism such as one-way valves, occlusion balloons, multi-lumen catheters, and other mechanisms. Pumps are provided for use in establishing the vacuum pressures that are either manual or motorized.

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and/or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

Catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially in the reduction of contrast-induced acute kidney injury. The catheter devices, systems and associated methods may prevent contrast dyes from entering into the kidney and/or facilitate blood flow beyond the kidney by utilization of the catheter devices, systems and associated methods.

A disposable device for treating a condition of a ureter or kidney having a cylindrical body about 1-2 mm in diameter by about 5 to 10 mm in length and having a top and bottom end. The body is made of absorbent material that expands upon contact with pharmaceutical agent and bodily fluids and includes a string connected to the bottom end of the body for removing the device. The device can be used to treat a condition of the ureter or kidney by inserting into the ureter or kidney, delivering a pharmaceutical agent, and removing the device after it has been impregnated with fluid. The device can be included in a kit with an insertion device and/or appropriate pharmaceutical agents.

Systems and methods for controlling an energy output setting of a lithotripsy device during a lithotripsy procedure are provided. The system includes a laser or other lithotripsy device configured for facilitating the lithotripsy procedure, an irrigation system configured for supplying an irrigant such as saline to a surgical site, and a temperature sensor configured to provide temperature data associated with the irrigant. The system can modulate the energy output setting of the lithotripsy device based on an estimated temperature that is determined based at least in part on the temperature data and one or more other factors such as a current energy output setting or a flow rate of the irrigant.

A catheter configured to be deployed in a urinary tract of a patient includes a proximal portion configured to pass through a percutaneous opening and a distal portion including a retention portion. The retention portion is configured to be deployed in a kidney, renal pelvis, and/or bladder of the patient. The retention portion includes one or more protected drainage holes, ports or perforations and is configured, when deployed, to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports, or perforations upon application of negative pressure through the catheter.

Several embodiments of a catheter are described, having a balloon configured to slowly inflate and then quickly deflate to create an area of low pressure in the vessels. The balloon can be cycled near the vessels of the kidneys, thereby helping to draw out blood from the kidneys and enhance fluid processing to the bladder.

Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.

Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.

A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.