A method of treating a human subject which is effected by inhalation of gaseous nitric oxide, the method comprising a first treatment period comprising administering gNO by inhalation over a period of about at least 5 days, wherein the first treatment period is followed by a second treatment period comprising administering gNO by inhalation over a period of at least 3 months. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.

The present invention includes an apparatus and method for breaking up mucus in a lung comprising: a chamber having an inlet and an outlet; a pressure oscillating unit in fluid communication with the chamber for supplying and vacuuming air into/out of the chamber, wherein the pressure oscillating unit creates ultrasound waves; a control unit for selecting a positive air pressure or a negative air pressure from the pressure oscillating unit, a fluid container in fluid communication with the chamber; a pressure sensor in fluid communication with the chamber; and an outlet connected to the chamber to send respiration gas to a patient, ultrasonic waves in the respiration gas are capable of breaking up mucus in the lung.

A respiratory monitoring device includes an electronic controller configured to: analyze an audio signal triggered during inspiratory and expiratory phases of a patient receiving mechanical ventilation therapy from a mechanical ventilator, the audio signal being acoustically coupled into the airway of the patient, to determine resonant frequencies of the airway; determine a shift in the resonant frequencies between the inspiratory and expiratory phases to determine a presence of pendelluft inside of a lung of the patient; and output an indication of the presence of pendelluft.

Oral gas catheters and methods of inducing gas in a patient orally. The oral gas catheter includes one or more delivery cannulas configured to be inserted into the patient's mouth with a distal end of the delivery cannula disposed adjacent the patient's laryngeal inlet, and a clip disposed on the delivery cannula. The clip is configured to secure the delivery cannula to a tooth of the patient. The oral gas catheter may have two such delivery cannulas and clips with the delivery cannulas coupled together by a coupler. The delivery cannulas are placed in an operative position in a patient's mouth and secured in the operative position by releasably securing the clips to the patient's teeth. The oral gas catheter makes it possible to bypass the nasal cavity and deliver oxygen or other gas directly adjacent the laryngeal entrance and into an anatomical dead space of the airway.

A Stylet device that allows for the articulation of tubing and provides a method for positioning of the tubing during intubation or other procedures while the tubing is located within a passage-way or lumen of a subject, such as an airway, organs, veins, intestines and the like. Where unique anatomical conditions are present in a subject, rendering standard intubation devices inadequate, the articulation capabilities of the apparatuses of the current invention are of particular use during methods of use and further promote the non-occlusion of the central cavity of the tube.

A liquid ventilation system includes a reservoir holding a perfluorochemical (“PFC”) fluid, and a suction pump connected to the reservoir to reduce pressure within the reservoir. A sensor is configured to measure an intra-lung pressure. An appliance is configured to be disposed within a patient. The appliance carries an injector to supply the PFC fluid through the appliance. An extraction valve is disposed on an extraction line between the appliance and the reservoir. The extraction valve is arrangeable between a first position enabling fluid communication from the appliance to the reservoir and a second position disabling fluid communication from the appliance to the reservoir.

An automated mechanical ventilator may include a positive pressure source that periodically delivers periodic positive pressure ventilations to a patient when a pressure within the patient's airway is greater than a predetermined threshold. The ventilator may include an inspiratory lumen coupled with the positive pressure source. The ventilator may include an inlet valve interfaced with the inspiratory lumen. The inlet valve may open with each positive pressure ventilation. The ventilator may include an expiratory lumen. The ventilator may include a pressure sensor in fluid communication with the expiratory lumen that senses the pressure within the patient's airway. The ventilator may include an outlet valve interfaced with the expiratory lumen. The ventilator may include a controller that opens the first valve without delivering a positive pressure ventilation when the pressure measured by the pressure sensor is less than the predetermined threshold.

A system for supporting pulmonary gas exchange in patients and for coupling to a ventilating system or for use in the case of non-ventilated patients, which has a flexible hose introducible into the trachea of a patient, a pump unit, a reservoir unit and a controller such that via the flexible hose and by means of the pump unit it is possible to regulate aspiration, especially end-expiratory aspiration, and recirculation, especially end-inspiratory recirculation, of the aspirated gas. In order that the system can be operated independently of a ventilating system, the system has a sensor.

Systems and techniques for monitoring, predicting and/or alerting for short-term oxygen support needs of patients are presented. A system can include a data collection component that receives multimodal patient data for a patient having a respiratory condition in association with monitoring and treating the respiratory condition in real-time, the multimodal patient data comprising at least physiological data regarding physiological parameters tracked for the patient over a period of time, and current oxygen support data regarding a current oxygen support mechanism of the patient. The system can further include an oxygen support forecasting component that processes the multimodal patient data using an oxygen support forecasting model to generate an output forecast that indicates whether a change to the current oxygen support mechanism is recommended for the patient within a defined upcoming timeframe

Devices, systems and methods are provided for controlling the operation of a breathing assistance device for a user. The controller may include an input for receiving sensor data to measure at least one airflow parameter of the user's airflow; a memory unit that stores at least one machine learning model and at least one classifier or predictor; and a processor that is configured to perform measurements and to generate a control signal for adjusting the operation of the breathing assistance device for a current monitoring time period by: obtaining measured air pressure and/or airflow data and measured FOT data during a current monitoring time period; performing feature extraction on the measured data to obtain feature values that are used by the machine learning model employed by the at least one classifier or predictor to determine a property of the user; and adjusting the control signal based on the determined property.