The present disclosure relates to determining a corrected exhaled gas measurement during high flow respiratory therapy. Measuring exhaled gas concentration during high flow respiratory therapy is difficult and inaccurate due to a phenomenon known as flushing. The high flows delivered to the patient flush the dead space in the conducting airways, which causes a dilution effect that results in underestimated or overestimated exhaled gas measurement depending on the gas composition delivered by the high flow system. This can lead to incorrect clinical measurements and diagnoses. Various algorithms are disclosed herein to account for the dilution effect caused by flushing, allowing for the method of measuring gas concentrations to still be used accurately for clinical measurements.

A transportable extracorporeal system includes a housing, a blood flow inlet, a blood flow outlet, a plurality of hollow gas permeable fibers, a gas inlet in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with outlets of the plurality of hollow gas permeable fibers, a first moving element, a concentrated oxygen generating device, a second moving element, a hollow transport conduit having a proximal opening and a distal opening and a power source configured to provide power to the first and second moving elements. The plurality of hollow gas permeable fibers comprising a gas transfer membrane. The concentrated oxygen generating device is configured to recycle waste oxygen from the gas transfer membrane to increase throughput and remove, by an adsorption/desorption process, unwanted gasses.

A transportable extracorporeal system includes a housing, a blood flow inlet, a blood flow outlet, a plurality of hollow gas permeable fibers, a gas inlet in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with outlets of the plurality of hollow gas permeable fibers, a first moving element, a concentrated oxygen generating device, a second moving element, a hollow transport conduit having a proximal opening and a distal opening and a power source configured to provide power to the first and second moving elements. The plurality of hollow gas permeable fibers comprising a gas transfer membrane. The concentrated oxygen generating device is configured to recycle waste oxygen from the gas transfer membrane to increase throughput and remove, by an adsorption/desorption process, unwanted gasses.

A method for determining a chance to enable a zeroing of gas analysis is disclosed herein. The method includes emitting radiation, and receiving emitted radiation, the received radiation comprising a first wavelength range absorbed by the at least one desired gas component and one or more disturbing factor, and a second wavelength range absorbed by the disturbing factor, the first wavelength range differing from the second wavelength range. The method also includes providing to a processing unit a first signal data indicative of a concentration of the at least one desired gas component and absorption of the disturbing factor, and a second signal data indicative of absorption of the disturbing factor. The method also includes determining a stability of the first and second signal data as a function of time, and if they are substantially stable enabling the zeroing to improve a measurement accuracy.

The present invention describes an apparatus and method for determining the energy expenditure of a subject by indirect calorimetry where respiratory gases O.sub.2 and CO.sub.2 are captured in a tent mask coupled through a pneumotach flow meter to a vacuum inlet of a blower fan whose speed is controlled by a computer running a program that ensures that the bias flow being drawn through the mask always exceeds the subject's peak expiratory flow. VO.sub.2 and VCO.sub.2 and flow values are measured on a breath-by-breath basis and used in arriving at a bias flow adjustment voltage to be applied to the blower fan for adjusting its speed.

Ventilation systems are provided. In one aspect, a ventilation system includes system includes a ventilation device that is configured to provide breathable air or gas mixture to a patient according to certain operating parameters, a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive, over a network, at least one of patient data, order data, configuration data, user data, or rules or protocols, and provide a modification of operating parameters of the ventilation device based on the received patient data, order data, configuration data, user data, or rules or protocols. Methods and machine-readable media are also provided.

A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

In one embodiment, a method for categorizing a state of a subject undergoing therapy from a mechanical ventilator is disclosed. The method includes receiving, at a device, one or more cardiovascular measurements regarding the subject, a respiratory rate from the ventilator, a carbon dioxide (CO.sub.2) measurement regarding the subject, and a tidal volume value from the ventilator. The method also includes selecting, by the device, a ventilation category based on the one or more cardiovascular measurements, the respiratory rate, the CO.sub.2 measurement, and the tidal volume value. The method further includes retrieving, by the device, an alert that is associated with the selected ventilation category. The method additionally includes providing, by the device, the alert to a user interface device.

A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.

Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired .sup.19F magnetic resonance image (MRI) signal data associated with the perfluorinated gas and oxygen mixture.