The present invention relates to a cutaneous device (2) for the storage and release of molecules, in particular therapeutic molecules, comprising: —a support (6), —a matrix (8) configured to store and release the molecules as a function of the temperature, and —an electro-resistive layer, disposed between the support and the matrix, intended to be subjected to a voltage and comprising at least one thin microporous and/or nanoporous metal layer. The present invention also relates to a transcutaneous delivery device and the corresponding methods of manufacture and use.

A wearable cardioverter defibrillator (WCD) system is configured to selectively provide cooling and/or heating to a component of the WCD system. In some embodiments, a Peltier device is used to provide the cooling to wearer of the WCD at or near where the WCDs defibrillation electrodes are positioned proximate or contacting the patient's body.

A wearable cardioverter defibrillator (WCD) system is configured to selectively provide cooling and/or heating to a component of the WCD system. In some embodiments, a Peltier device is used to provide the cooling to wearer of the WCD at or near where the WCDs defibrillation electrodes are positioned proximate or contacting the patient's body.

A therapeutic apparatus for treating damaged tissue on a limb or body of a subject includes a wearable adapted to cover and be secured to the limb or body of a subject over damaged tissue. The wearable being configured to reduce pressure on the damaged tissue and adapted to deliver one or more treatments selected from the group consisting of heat, oxygen, electrical current, and light to the damaged tissue.

A therapeutic apparatus for treating damaged tissue on a limb or body of a subject includes a wearable adapted to cover and be secured to the limb or body of a subject over damaged tissue. The wearable being configured to reduce pressure on the damaged tissue and adapted to deliver one or more treatments selected from the group consisting of heat, oxygen, electrical current, and light to the damaged tissue.

A wearable cardioverter defibrillator (WCD) system is configured to selectively provide cooling and/or heating to a component of the WCD system. In some embodiments, a Peltier device is used to provide the cooling to wearer of the WCD at or near where the WCDs defibrillation electrodes are positioned proximate or contacting the patient's body.

A wearable cardioverter defibrillator (WCD) system is configured to selectively provide cooling and/or heating to a component of the WCD system. In some embodiments, a Peltier device is used to provide the cooling to wearer of the WCD at or near where the WCDs defibrillation electrodes are positioned proximate or contacting the patient's body.

A neuromodulation catheter in accordance with a particular embodiment includes an elongate shaft and a neuromodulation element operably connected to the shaft. The shaft includes a proximal hypotube segment at its proximal end portion and a jacket disposed around at least a portion of an outer surface of the hypotube segment. The jacket may be made at least partially of a polymer blend including polyether block amide and polysiloxane. The neuromodulation element includes a distal hypotube segment and a tubular jacket disposed around at least a portion of an outer surface of the distal hypotube segment. The jacket has reduced-diameter segments spaced apart along its longitudinal axis. The neuromodulation element further includes band electrodes respectively seated in the reduced-diameter segments and respectively forming closed loops extending circumferentially around the jacket.

A neuromodulation catheter in accordance with a particular embodiment includes an elongate shaft and a neuromodulation element operably connected to the shaft. The shaft includes a proximal hypotube segment at its proximal end portion and a jacket disposed around at least a portion of an outer surface of the hypotube segment. The jacket may be made at least partially of a polymer blend including polyether block amide and polysiloxane. The neuromodulation element includes a distal hypotube segment and a tubular jacket disposed around at least a portion of an outer surface of the distal hypotube segment. The jacket has reduced-diameter segments spaced apart along its longitudinal axis. The neuromodulation element further includes band electrodes respectively seated in the reduced-diameter segments and respectively forming closed loops extending circumferentially around the jacket.

Catheter apparatuses, systems, and methods for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral/helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).