A therapeutic apparatus for treating damaged tissue on a limb or body of a subject includes a wearable adapted to cover and be secured to the limb or body of a subject over damaged tissue. The wearable being configured to reduce pressure on the damaged tissue and adapted to deliver one or more treatments selected from the group consisting of heat, oxygen, electrical current, and light to the damaged tissue.

Catheter apparatuses, systems, and methods for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral/helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).

Catheter apparatuses, systems, and methods for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral/helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).

A surgical instrument includes a housing having a shaft extending distally therefrom, an end effector assembly disposed at a distal end of the shaft, a handle assembly coupled to the housing for manipulating the end effector assembly, a deployable assembly, at least one actuator for deploying and retracting the deployable assembly, and a closure member. The closure member is keyed to the actuator(s) and operably positioned relative to the movable handle of the handle assembly such that, upon rotation of the actuator(s) relative to the housing from an un-actuated position to an actuated position, the closure member is urged into contact with the movable handle to urge the movable handle from an initial position to a compressed position, thereby moving the end effector assembly to an approximated position.

A surgical instrument includes a housing having a shaft extending distally therefrom, an end effector assembly disposed at a distal end of the shaft, a handle assembly coupled to the housing for manipulating the end effector assembly, a deployable assembly, at least one actuator for deploying and retracting the deployable assembly, and a closure member. The closure member is keyed to the actuator(s) and operably positioned relative to the movable handle of the handle assembly such that, upon rotation of the actuator(s) relative to the housing from an un-actuated position to an actuated position, the closure member is urged into contact with the movable handle to urge the movable handle from an initial position to a compressed position, thereby moving the end effector assembly to an approximated position.

A neuromodulation catheter in accordance with a particular embodiment includes an elongate shaft and a neuromodulation element operably connected to the shaft. The shaft includes a proximal hypotube segment at its proximal end portion and a jacket disposed around at least a portion of an outer surface of the hypotube segment. The jacket may be made at least partially of a polymer blend including polyether block amide and polysiloxane. The neuromodulation element includes a distal hypotube segment and a tubular jacket disposed around at least a portion of an outer surface of the distal hypotube segment. The jacket has reduced-diameter segments spaced apart along its longitudinal axis. The neuromodulation element further includes band electrodes respectively seated in the reduced-diameter segments and respectively forming closed loops extending circumferentially around the jacket.

A neuromodulation catheter in accordance with a particular embodiment includes an elongate shaft and a neuromodulation element operably connected to the shaft. The shaft includes a proximal hypotube segment at its proximal end portion and a jacket disposed around at least a portion of an outer surface of the hypotube segment. The jacket may be made at least partially of a polymer blend including polyether block amide and polysiloxane. The neuromodulation element includes a distal hypotube segment and a tubular jacket disposed around at least a portion of an outer surface of the distal hypotube segment. The jacket has reduced-diameter segments spaced apart along its longitudinal axis. The neuromodulation element further includes band electrodes respectively seated in the reduced-diameter segments and respectively forming closed loops extending circumferentially around the jacket.

Diathermy device comprising a generator of alternating electric current and an electrode, the electrode and the generator being electrically connected, and characterised in that the electrode consists of a flexible glove comprising an inner layer of insulating material, an intermediate conducting layer connected to the generator and an outer layer made of an insulating material with a thickness of between 0.05 and 0.15 mm such that the outer layer has an impedance of less than 50 ohms for alternating electric currents with a frequency of between 100 kHz and 10 MHz, and in that the generator is configured to generate alternating electric currents at least at a frequency within said interval of 100 kHz and 10 MHz.

Diathermy device comprising a generator of alternating electric current and an electrode, the electrode and the generator being electrically connected, and characterised in that the electrode consists of a flexible glove comprising an inner layer of insulating material, an intermediate conducting layer connected to the generator and an outer layer made of an insulating material with a thickness of between 0.05 and 0.15 mm such that the outer layer has an impedance of less than 50 ohms for alternating electric currents with a frequency of between 100 kHz and 10 MHz, and in that the generator is configured to generate alternating electric currents at least at a frequency within said interval of 100 kHz and 10 MHz.

One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.