A device for transcutaneous electrical stimulation is provided. The device comprises circuitry configured to generate transcutaneous stimulation signals. The device also comprises a first signal output component for electrically connecting to a first electrode connector to deliver generated transcutaneous stimulation signals. The first signal output component comprises a first four-pole electrical connector part. The device further comprises a second signal output component for electrically connecting to a second electrode connector to deliver generated transcutaneous stimulation signals. The second signal output component comprises a second four-pole electrical connector part. The device further comprises a controller to selectively control output of the stimulation signals to selected pairs of poles across the first and second four-pole electrical connector parts. Each selected pair of poles comprises one pole from the first four-pole electrical connector part and one pole from the second four-pole electrical connector part.

Various examples are provided for simultaneous bilateral brain stimulation. In one example, a method includes applying a first stimulation signal at a first frequency through a feature-side implanted neural stimulator (INS) on a first side of a brain, applying a second stimulation signal at a second frequency through a non-feature-side INS on a second side of the brain, and detecting a stimulation interference signal with the non-feature-side INS. The first stimulation signal can be a pulsed signal and the second simulation signal can be a continuous signal at a low stimulation voltage, and the stimulation interference signal at an interference frequency based upon the first and second frequencies. In another example, a neural stimulation system including a feature-side neural stimulator and a non-feature-side neural stimulator implanted on first and second sides of the brain and neural stimulation circuitry coupled to the neural stimulators.

A wellness device is provided that utilizes interference frequencies. The wellness device applies frequencies modulated by one another to interfere with one another to create a unique frequency delivery to achieve a desired result.

An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.

In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

In exemplary implementations of this invention, stimuli are intermittently presented to the left or right side of a user. For example, this invention may comprise a method of presenting stimuli to a bilateral organism, which organism has a left side and a right side, wherein: (a) the stimuli are produced by at least one transducer, (b) the stimuli include an intermittent beat train, and (c) the beat train has a beat frequency that is substantially equal to 7.8×(1.618).sup.n Hz, where n is an even integer, which even integer may be negative, zero or positive.

The invention relates to a system for electrical and/or magnetic neuronal stimulation, comprising a signal generator for generating a stimulation signal, in particular an alternating-current stimulation signal, an applicator for applying the stimulation signal, in particular in an area on or directly around the optic nerve, a lead for deriving a measurement signal, in particular an EEG signal, a biomarker calculation unit for calculating a biomarker based on the measurement signal, and an optimization unit, in particular for performing a stochastic optimization process, for optimizing the value of the biomarker by varying the stimulation signal.

A method for treating diagnosed or suspected tumors of a subject, comprising obtaining a target map that identifies an actual or likely location of the tumor in the subject, and providing multifocal non-invasive electrical stimulation with a duration, spatiotemporal pattern, current intensity, electrode montage, and/or regimen sufficient to do one or more of the following: (1) reduce the size of one or more tumor(s), (2) alter its/their perfusion, (3) change its/their metabolic or electrical activity, (4) change its/their functional connectivity profile, (5) slow down or stop its/their progression/spread and related symptomatology, (6) characterize one or more tumor(s) based on its/their response to noninvasive brain stimulation; possibly in conjunction with optimized anatomical changes applied to the skin or skull to better steer currents and fields into the tumor.

Neurostimulation devices and methods provide a plurality of electrodes placed around a patient head such that electrode have electrical paths through the brain to other electrodes. A controller controls current between sets of opposing electrodes through the patient brain to selectively stimulate a region of interest of the patient brain. Different sets of electrodes are used to provide electrical current pulse with different polarities such that a net potential is exposed to a region of interest in the brain that it above a neuron stimulation threshold while a net potential exposed to tissue outside the region of interest is below the threshold.