The present invention provides a wearable device, a system for manufacturing a wearable device and a method of neural activity control. The device for temporal interference simulation includes a pair of electrodes at penalizable location. The electrodes each send out a high frequency electromagnetic fields with a very slight difference in the two frequencies. The fields superimpose at a specified region of the brain, which is customized depending on the location of neural activity control, to create a low frequency refractory wave envelope. The low frequency wave inhibits or stimulates local neurons to control electrical activity within that region.

The present invention relates to a medical treatment device for stimulating neurons of a patient. The device comprises a first non-invasive stimulating device for generating at least two different first stimuli to a patient's body, a second non-invasive stimulating device for generating at least two different second stimuli to the patient's body, and a control unit for selectively and intermittently actuating the stimulating devices. In a first operating mode, the control unit is configured to actuate the first stimulating device in a sequence of successive actuating periods such that a number n of first stimuli to be generated simultaneously during the actuating periods is variedly determined across the sequence and to actuate the second stimulating device so as to generate the second stimuli to be paired to the generation of at least a part of the first stimuli. In a second operating mode, the control unit is configured to actuate the second stimulating device so as to generate the second stimuli to be de-coupled from the generation of at least a part of the first stimuli.

A neuromodulator includes an electromagnetic (EM) wave generator configured to generate EM waves remote from a patient and to direct the EM waves to one or more target regions within the patient. Frequencies of the EM waves fall outside a range of frequencies that activates neurons. Intersection of the EM waves in each target region creates envelope-modulated electric and magnetic fields having one or more frequencies that fall within the range of frequencies that activates neurons. The neuromodulator includes control circuitry configured to control parameters of the EM waves produced by the EM wave generator. The neuromodulator may use feedback based on one or more of patient input and/or sensing of physiological signals in order to close the loop and control the EM waves.

Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.

Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

Systems and methods for treating symptoms of an inflammatory gastrointestinal disease in a patient with transcutaneous stimulation of a peripheral nerve are disclosed. The method can include any number of positioning a first peripheral nerve effector on the patient's skin to stimulate the peripheral nerve of the patient, delivering a first electrical nerve stimulation signal transcutaneously to the peripheral nerve through the first peripheral nerve effector, and modifying at least one brain or spinal cord autonomic feedback loop relating to release of neurotransmitters from the autonomic nervous system that modulate synthesis of inflammatory biomarkers and reduce inflammation relating to the inflammatory gastrointestinal disease.

An electrical interferential technique is used to determine operable treatment parameters which are then used to apply a treatment to a patient. A range of beat frequencies is applied to the patient and an indicator of autonomic nervous system activity is measured. When some degree of autonomic nervous system activity is detected, a subsequent trial is conducted using an overlaying range of frequencies, a narrower range or a single frequency, in an attempt to fine tune the reaction of the autonomic nervous system. The subsequent trial may use a different measure of activity of the autonomic nervous system. A garment having a series of electrode sites thereon may be used for a partially trained person to correctly apply electrodes to the patient's body. The treatments may be conducted while the patient is asleep.

In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.

A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.