Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

A method and apparatus to treat hyperhidrosis is provided in which a battery provides a milliampere electrical current to the inside of a waterproof glove containing water and sealed to the user's arm so that circulation is not unduly restricted while the user can raise the water-filled gloves and hands above the user's head without leaking. A tapered portion on the proximal end of each glove is folded inside the glove to seal against the user's arm to form a pocket between the tapered portion which seals against the user's arms, and part of a wrist portion of the glove located radially outward of the tapered portion. When the user's gloves and hands rotate upward, water collects in the pocket(s) while the tapered portion provides a leakproof seal, thus allowing manual manipulation while wearing the water-filled gloves.

An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.

Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.

Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.

Systems, apparatus, and methods are described for delivering a therapeutic substance, such as an anesthetic, to a tympanic membrane of a subject. Such systems can include an earset with a valve configured to control flow of a fluid, such as air, into and out of a reservoir. In some embodiments, systems, apparatus, and methods described herein can include additional valves and features for relieving negative pressure within the reservoir.

Disclosed is an activation device. The activation device, which serves as a device coming into contact with an object to activate surrounding materials according to a dielectric barrier discharge principle, includes: a dielectric having a predetermined thickness and formed with an outer surface coming into contact with the object and an inner surface facing the outer surface; and an electrode provided inside the dielectric and having an outer surface facing the inner surface of the dielectric, wherein the outer surface of the electrode includes a contact area that comes into contact with the inner surface of the dielectric, and a non-contact area that does not come into contact with the inner surface of the dielectric.

Provided is a needle assembly including: a plurality of needles; a main body having a plurality of holes through which the plurality of needles pass in a first direction; and a fixing member coupled to the main body and having a plurality of fixed inclined surfaces supporting the plurality of needles.

Described are methods and devices (100) for measuring a sweat property of skin (12) in response to at least one test material or component (172, 174, 176, 178). Embodiments of the device include a plurality of different sweat stimulation sites. The Sweat stimulation sites may include one or more sweat stimulant reservoirs (142, 144, 146, 148) configured to deliver a sweat stimulant to the surface of the skin (12). Embodiments may also include at least one electrode (150, 152, 154, 156, 158) for measuring a sweat property or to iontophoretically deliver the sweat stimulant from the reservoir (142, 144, 146, 148). In embodiments, the sweat stimulant is selected from acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, and combinations thereof.

Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of a stimulating agent. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficient collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.