The present invention provides a system and a method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. A result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize an electrical treatment for a particular target cell or cellular tissue.

A system and method for altering bone growth on and within an orthopedic implant that includes an implant body; a plurality of electrodes, wherein each electrode is at least partially embedded in the implant body, and comprises: a set of primary electrodes comprising at least one electrode, wherein a non-embedded segment of each primary electrode is proximal to a bone growth region, a set of secondary electrodes comprising at least one electrode, wherein a non-embedded segment of each secondary electrode is distal to the bone growth region, and wherein the plurality of electrodes are configured to function in a stimulation operating mode, such that a subset of primary electrodes function as cathodes and a subset of secondary electrodes function as anodes; a control system comprising a processor, and circuitry that connects to the plurality of electrodes; and a power system.

The invention relates to a device (10) for supporting a treatment using pulsed electric fields in order to heal wounds and/or for the inactivation of microorganisms. The device comprises an electric energy storage device (16), a pulse generator (17) for providing electric excitation pulses, a transformer (26) for providing high-frequency electric pulses (200) on an output side (28), a first connection of the input side (27) of the transformer (26) being connected to the pulse generator (17), and a treatment instrument (100) which comprises a closed body (102) made of an electrically insulating material and an electrode (110) arranged in the interior of the body (102). A gas or a gas mixture is received in the interior of the body (102), and the treatment instrument (100) is designed to discharge gas in the event of an electric excitation. A first end (103) of the treatment instrument (100) is designed to couple to a first connection of the output side (28) of the transformer (26). Furthermore, a second end (104) of the treatment instrument (100) is designed to contact surfaces and/or biological tissue, and a second connection of the output side (28) of the transformer (26) is connected to a second connection of the input side (27) of the transformer (26) and a housing shielding (13). The housing shielding (13) is electrically insulated from the outer environment by a housing of the device and is thus designed as an ungrounded mass, and the transformer (26) and the pulse generator (17) are designed such that the high-frequency electric pulses (200) have a frequency ranging from 10 kHz to 100 kHz and a pulse repetition rate ranging from 100 kHz to 400 kHz. The invention additionally relates to a method for the inactivation of microorganisms, wherein such a device (10) is provided, and the treatment instrument (100) of the device (10) is excited with high-frequency electric pulses.

A device to stimulate a scalp comprises an array of stimulating elements, the stimulating elements arranged along a circumference of at least one wheel, the wheel adapted to roll over the scalp. A method of treating/preventing a hair-condition comprises: subjecting the scalp to at least 200 distinct electrode-scalp contact events during a time-interval of at most one minute and dividable into 5 non-overlapping equal-duration sub-intervals covering the time-interval, method performed such that i. for at least a majority of the electrode-scalp contact events, no electrode of the event enters into the dermis; ii. a duration of each electrode contact event is at most 100 milliseconds; and iii. for each electrode contact event, an electrical current flows between the electrode and the scalp so as to deposit electrode-released ions of a first metal or of a second metal on the scalp, thereby forming a respective metal-ion-deposition island on the user's scalp.

Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and/or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and/or the motion data, thereby improving patient compliance with a prescribed therapy regimen.

The present invention relates to electro-therapy of wounds. Specifically, a device for electro-therapy of wounds and a method for applying electro-therapy to a wound is provided. The device and the method of the invention is useful for treating any kind of wound and is especially useful for facilitating the healing of chronic wounds.

The present invention relates to electro-therapy of wounds. Specifically, a device for applying electro-therapy to a wound is provided. The device of the invention is useful for treating any kind of wound, and is especially useful for facilitating the healing of chronic wounds.

Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with a remote server for patient monitoring, prescription and/or device servicing.

Provided herein methods and systems for triggering osteogenesis and promoting osteointegration on dental implants.

To achieve in vivo repair of severed mammalian nerve tissue, a system can be employed to induce distraction neurogenesis. At least a portion of the system can be anchored at an injury site, such as between distal and proximal nerve ends. The system can be attached to the proximal nerve end and can place the nerve under micro-tension for an extended period of treatment. The system may also deliver medication or treatment to encourage neurogenesis and to reduce pain in the subject receiving treatment. After the course of treatment, the device can be removed from the injury site, and the nerve ends rejoined.