Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.

A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.

The present invention provides for the intratumoral delivery of at least one immunostimulatory cytokine in combination with at least one checkpoint inhibitor. In particular, it provides delivery of a plasmid encoding the immunostimulatory cytokine using intratumoral electroporation. The checkpoint inhibitor may be administered systemically or encoded on a plasmid and delivered using intratumoral electroporation. The checkpoint inhibitor may be delivered contemporaneously with or after treatment with the immunomodulatory cytokine.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for electroporation ablation. The electroporation catheter may include an electrode assembly comprising one or more ablation electrodes configured to generate electric fields proximate to target tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections, and one or more mapping electrodes configured to measure cardiac electrical signals. In some embodiments, the measured electrical signals are used to create an electro-anatomical map.

A device and method are disclosed for regulated storage capacitor charging to high voltage. The device comprises an AC source configured to output an AC voltage, a voltage multiplier that constitutes a charging unit and a control unit. The control unit is configured to constantly sense the voltage on the storage capacitor and upon detecting that a predefined maximum charging voltage has been reached to react in at least one of the following ways: stop charging the storage capacitor, and closing an output switch so as to discharge of the storage capacitor through some load. The capacitance of each capacitor in the charging unit is substantially smaller than that of the storage capacitor so as achieve accurate maximum charging voltage as well as limited charging current.

A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 μs and 5 μs, an inter-pulse delay of at least 5 μs, and a pulse width of 5 μs.

A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.

An injection device for in vivo delivery of an agent includes a tubular body defining a lumen that extends along a central axis that is oriented along a longitudinal direction. A distal end of the lumen is occluded and the tubular body defines at least one side-port extending from the lumen to an outer surface of the tubular body. The at least one side-port is elongated along the outer surface of the tubular body.

A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bipolar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into, the extracellular space without denaturing proteins so as to enable an immunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

According to certain embodiments, a wearable electronic device comprises: a housing; a first electrode and a second electrode disposed on the housing; an A/D converter connected to the first electrode and the second electrode; a pulse generator connected to the first electrode and the second electrode; and a processor operatively connected to the A/D converter and the pulse generator; wherein the processor is configured to: control the pulse generator to output a series of pulse waves to the first electrode when an external object is in contact with the first electrode; and controlling the A/D converter to obtain biometric information from the first electrode and second electrode in response to outputting the series of pulse waves.