Methods and devices for treating a targeted tissue including a skin or a lip and more particularly methods and devices that enhances absorption of treatment media into tissue for cosmetic and therapeutic purposes.

An exemplary apparatus, can include, for example, a circulating tumor cell (CTC) treatment arrangement, a pump arrangement configured to circulate a fluid through the CTC treatment arrangement, and an electric field generator electrically connected to the CTC treatment arrangement, and configured to apply an electric field to the fluid circulating through the CTC treatment arrangement. The pump arrangement can be a peristaltic pump, which can be configured to continuously circulate the fluid through the CTC treatment arrangement. According to another exemplary embodiment of the present disclosure, method, system and computer-accessible medium can be provided for killing at least one circulating tumor cell (CTC). Using such exemplary embodiment, blood can be pumped from a body of a patient to an electroporation chamber inside of a CTC treatment arrangement. An electric field can be applied to the blood located in the electroporation chamber in order to kill the CTC. The electric field-applied blood can be pumped back into the body.

This disclosure describes methods systems, and devices for treating atrial and ventricular fibrillation. For example, this document describes a method of terminating cardiac arrhythmias that includes generating a bipolar pulsed electrical field between a first electrode positioned on a first portion of a heart of a patient and a second electrode positioned on a second portion of the heart of the patient to cause reversible electroporation of myocardial cells of the heart.

A method for adjusting the operation of a surgical suturing instrument using machine learning in a surgical suite is disclosed. The method comprises gathering data during surgical procedures, wherein the surgical procedures include the use of a surgical suturing instrument comprising a suturing needle configured to be mechanically advanced through a suturing stroke, analyzing the gathered data to determine an appropriate operational adjustment of the surgical suturing instrument, and adjusting the operation of the surgical suturing instrument to improve the operation of the surgical suturing instrument.

The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.

An electroporation device includes a shaft and a conformable electrode assembly. The shaft includes a proximal end and a distal end, wherein the conformable electrode assembly is located at the distal end of the shaft. The electrode assembly has a first side and a second side, wherein the first side includes a first non-conductive portion and a first electrode centrally located on the first side. The first non-conductive portion is defined by a first surface area and the first electrode is defined by a second surface area, wherein the first surface area is greater than the second surface area.

An assay device and method of assaying the application of energy to a plurality of samples in vitro. The assay device includes a housing, an array, and a control module. The housing includes a socket sized to receive a culture plate. The array includes a plurality of emitters and is positioned within the housing adjacent to the socket so that the plurality of emitters are each aligned with at least one culture well of the culture plate when the culture plate is received in the socket. The control module is operably coupled to the array and is configured to individually drive the plurality of emitters. The control module is configured to drive at least two of the plurality of emitters at different frequencies simultaneously.

Presented herein are dual-function surgical tools for insertion of implantable stimulating assemblies, such as intra-cochlear stimulating assemblies. In addition to facilitating intra-operative positioning of a stimulating assembly within a recipient (e.g., operating to guide the stimulating assembly of an implantable medical device into position), the surgical tool also includes a plurality of electrodes configured to apply an electroporation electrical field to a recipient's nerve cells to enable introduction of treatment substance into the nerve cells.

A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surface define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.