An exemplary system, method and computer-accessible medium for determining an effect(s) of a convulsive stimulation therapy(ies) on a patient(s) can be provided, which can include, for example, receiving first information related to a visual network or a default mode network of a brain of the patient(s), receiving second information related to a subgenual ACC or a default mode (DMN network of the brain of the patient(s), and determining the effect(s) of the convulsive stimulation therapy(ies) based on a relationship between the first information and the second information. The convulsive stimulation therapy(ies) can be an electroconvulsive therapy or a magnetic seizure therapy.

An exemplary system, method and computer-accessible medium for determining an effect(s) of a convulsive stimulation therapy(ies) on a patient(s) can be provided, which can include, for example, receiving first information related to a visual network or a default mode network of a brain of the patient(s), receiving second information related to a subgenual ACC or a default mode (DMN network of the brain of the patient(s), and determining the effect(s) of the convulsive stimulation therapy(ies) based on a relationship between the first information and the second information. The convulsive stimulation therapy(ies) can be an electroconvulsive therapy or a magnetic seizure therapy.

Several defibrillators, defibrillator architectures, defibrillator components and methods of operating defibrillators are described. In one aspect, a defibrillator (as for example an automated external defibrillator) that can be powered by a mobile communication device such as a smart cellular phone or a tablet computer is described. Utilizing a phone (or other mobile communication device) as the power supply for an external defibrillator allows the external defibrillator to be smaller and, in some circumstance, removes the need for a battery that stores sufficient energy for shock delivery—which would need to be checked and/or replaced on a regular basis. Additionally, when desired, certain control functionality, computation, data processing, and user instructions can be handled/presented by the mobile communications device thereby further simplifying the defibrillator design and improving the user experience. This architecture takes advantage of the nearly ubiquitous availability of smart phones, tablet computers and other mobile communication devices.

Several defibrillators, defibrillator architectures, defibrillator components and methods of operating defibrillators are described. In one aspect, a defibrillator (as for example an automated external defibrillator) that can be powered by a mobile communication device such as a smart cellular phone or a tablet computer is described. Utilizing a phone (or other mobile communication device) as the power supply for an external defibrillator allows the external defibrillator to be smaller and, in some circumstance, removes the need for a battery that stores sufficient energy for shock delivery—which would need to be checked and/or replaced on a regular basis. Additionally, when desired, certain control functionality, computation, data processing, and user instructions can be handled/presented by the mobile communications device thereby further simplifying the defibrillator design and improving the user experience. This architecture takes advantage of the nearly ubiquitous availability of smart phones, tablet computers and other mobile communication devices.

Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.

A valvuloplasty system comprises a balloon adapted to be placed adjacent leaflets of a valve. The balloon is inflatable with a liquid. The system further includes a shock wave generator within the balloon that produces shock waves. The shock waves propagate through the liquid and impinge upon the valve to decalcify and open the valve.

A valvuloplasty system comprises a balloon adapted to be placed adjacent leaflets of a valve. The balloon is inflatable with a liquid. The system further includes a shock wave generator within the balloon that produces shock waves. The shock waves propagate through the liquid and impinge upon the valve to decalcify and open the valve.

An ElectroConvulsive Therapy (ECT) device for generating a series of electrical therapeutic pulses for delivery to a patient to cause a seizure includes a user interface configured to accept one or more therapy settings from a user, a therapy generator configured to generate the series of electrical therapeutic pulses, and a therapy delivery system structured to apply the series of electrical therapeutic pulses to the patient. The ECT device further includes a power monitor configured to measure average electrical power that is being delivered to the patient through the series of electrical therapeutic pulses in real-time during a treatment session, and to cause the therapy generator to cease operation after a predetermined threshold level of average electrical power has been delivered to the patient. Related methods are also disclosed.

An ElectroConvulsive Therapy (ECT) device for generating a series of electrical therapeutic pulses for delivery to a patient to cause a seizure includes a user interface configured to accept one or more therapy settings from a user, a therapy generator configured to generate the series of electrical therapeutic pulses, and a therapy delivery system structured to apply the series of electrical therapeutic pulses to the patient. The ECT device further includes a power monitor configured to measure average electrical power that is being delivered to the patient through the series of electrical therapeutic pulses in real-time during a treatment session, and to cause the therapy generator to cease operation after a predetermined threshold level of average electrical power has been delivered to the patient. Related methods are also disclosed.

The present disclosure provides a method of preventing or treating depression in a subject in need thereof, including administering to the subject an effective amount of benzoic acid, or a salt or derivative thereof. Also provided is a composition for use in preventing or treating depression in a subject in need thereof.