An instrument for therapeutically cytotoxically ablating parathyroidal tissue is disclosed. A substance is capable of transforming the parathyroid gland from overproduction of parathyroid hormone when the substance's quantity exceeds a set amount, and is capable of transforming the parathyroid gland from overproduction only when activated by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the substance's quantity is below the set amount. A delivery device is operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity to below the set amount. An energy device is operable to apply units of the electromagnetic energy after the substance has been introduced. A sensor is operable to monitor the activation of the substance as the electromagnetic energy is applied. The energy device is further operable to modulate applying the electromagnetic energy when the substance has been activated.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ.sub.1, to generate a second wavelength λ.sub.2 of radiation having a higher energy than the first wavelength λ.sub.1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

The disclosure describes a heat delivery medium and composition for biomedical applications with controlled conversion of energy from an exogenous source to heat.

A method for early stage pathology detection, location, imaging, evaluation, and treatment of cells and/or extracellular vesicles in the circulation.

[Summary] [Problem] The therapy method and the therapy apparatus for difficult cancer such as ductal cancer and other diseases. [Solution to problem] The therapy and the apparatus to beat cancer and other diseases by injecting the material which is energy receptive from outside and emissive heat to cancer cells in the body of a patient, and giving energy from outside.

Disclosed are methods of altering the electric impedance to an alternating electric field in a target site of a subject, comprising introducing a nanoparticle to a target site in the subject; and applying an alternating electric field to the target site of the subject, wherein the electric impedance in the target site of the subject to the alternating current is altered. Disclosed are methods for improving transport of a nanoparticle across a cell membrane of a cell, the method comprising applying an alternating electric field to the cell for a period of time, wherein application of the alternating electric field increases permeability of the cell membrane; and introducing the nanoparticle to the cell, wherein the increased permeability of the cell membrane enables the nanoparticle to cross the cell membrane. Disclosed are methods of imaging a cancer cell, the method comprising applying a first alternating electric field at a first frequency to the cancer cell for a first period of time, wherein application of the first alternating electric field at the first frequency to the cancer cell for the first period of time increases permeability of cell membranes of the cancer cell; introducing a nanoparticle to the cancer cell, wherein the increased permeability of the cell membranes enables the nanoparticle to cross the cancer cell membrane; and imaging the cancer cell.

A vaginal device is described. A conformable vaginal insert is shaped for insertion into a vaginal cavity of a female human. A contact point is configured to change a shape of the insert. A sensor is configured to measure and to relay characteristics of the vaginal cavity and the surrounding and supportive structures of the vaginal cavity. A processor is configured to control the contact point to adjust the shape of the insert, generate a treatment for the vaginal cavity and the surrounding structures of the vaginal cavity and the supportive structures of the vaginal cavity comprising a vaginal cavity profile generated from the measured characteristics, store the measured characteristics and the vaginal cavity profile, and based on the stored measured characteristics and the stored vaginal cavity profile, automatically modify the shape of the insert by control of the contact point to provide the treatment to the vaginal cavity.

An example implantable microparticle for delivering therapeutic heat treatment comprises a generally spherical body. The body may be formed from a first material comprising a biodegradable material and a second material comprising a Curie temperature material. The biodegradable material may be a non-Curie temperature material or have a Curie temperature lower than a Curie temperature of the Curie temperature material. The first material and the second material are mixed to form a composite having a Curie temperature in the range of 35° C. and 100° C.

A nanoagent for detections and treatments of multiple targets of interest includes multiple types of nanocomposites, each type of nanocomposites comprising at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a respective reporter assembled on the shell of each nanostructure; and a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter. In use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.

A system for deploying a shape memory catheterization device within a patient, includes a catheter for endovascular insertion of the shape memory catheterization device. A heat source heats the shape memory catheterization device above the transition temperature. A transformation data generator includes a circuit driver for driving a circuit that includes at least one strain gage of the shape memory catheterization device and a detection circuit for generating transformation data based on a strain indicated by the at least one strain gage, wherein the transformation data indicates a shape transformation of the shape memory catheterization device from a catheterization shape to a transformed shape.