[Summary]

[Problem]

The therapy method and the therapy apparatus for difficult cancer such as ductal cancer and other diseases.

[Solution to problem]

The therapy and the apparatus to beat cancer and other diseases by injecting the material which is energy receptive from outside and emissive heat to cancer cells in the body of a patient, and giving energy from outside.

[Selected drawing]FIG. 8

A method of killing cells of a targeted cell type in a patient body that utilizes nanoparticles having a first portion, which when exposed to a target portion of a targeted cell type, binds to the target portion and a second portion, joined to the first portion, and comprised of a low resistivity material. The nanoparticles are introduced into a contact area where they contact cells of the targeted cell type. Contemporaneously, the contact area is exposed to a varying magnetic field of insufficient strength to increase the temperature of any part of the patient body by more than ten degrees Celsius, but which creates a current at the nanoparticles sufficient to disrupt function of the targeted cell type.

[Summary] [Problem] The therapy method and the therapy apparatus for difficult cancer such as ductal cancer and other diseases. [Solution to problem] The therapy and the apparatus to beat cancer and other diseases by injecting the material which is energy receptive from outside and emissive heat to cancer cells in the body of a patient, and giving energy from outside.

The present invention concerns a system for treating cancer or tumors by thermotherapy, comprising an expandable implant device, an excitation catheter and an electric power source, wherein the implant device configured for circumferentially subtending a vessel upon expansion of the implant device in said vessel, the implant device comprising a set of cross-connected conductors forming a circumferential structure with openings in between the conductors, said openings having a minimal opening distance when the implant device is expanded of at least 2 mm, wherein the excitation catheter comprises a longitudinal shaft with a distal end, a proximal end, and a longitudinal body in between, whereby the catheter comprises a longitudinal axis along the longitudinal shaft, and whereby the catheter further comprises an emitter coil at or near the distal end, and whereby the longitudinal body of the catheter further comprises a wiring lumen comprising electrical wiring extending from the distal end to the proximal end, and whereby the electrical wiring is connected at or near the distal end with the emitter coil, and wherein the electric power source is connectable, and preferably connected, to the wiring via the proximal end of the catheter shaft for the generation of a time-varying magnetic field with the emitter coil.

Systems and devices for pulsed heating of the ST36 acupoint and/or other acupoint(s) by noninvasive transcutaneous magnetic induction heating towards (1) ameliorating cognitive impairment arising, for example, from head-injury, stroke, and neurodegenerative diseases such as Alzheimer's; (2) helping to prevent neurodegenerative diseases; (3) preventing and treating age-related cognitive decline; and (4) preventing and treating depression manifesting, for example, as Major Depressive Disorder, Dysthymic Disorder, or Adjustment Disorder with Depressed Mood.

In this study, we demonstrated a unique application of our Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD) technique for the de-crystallization of uric acid crystals, which causes gout in humans when monosodium urate crystals accumulate in the synovial fluid found in the joints of bones. Given the shortcomings of the existing treatments for gout, we investigated whether the MAMAD technique can offer an alternative solution to the treatment of gout. Our technique is based on the use of metal nanoparticles (i.e., gold colloids) with low microwave heating to accelerate the de-crystallization process. In this regard, we employed a two-step process; (i) crystallization of uric acid on glass slides, which act as a solid platform to mimic a bone, (ii) de-crystallization of uric acid crystals on glass slides with the addition of gold colloids and low power microwave heating, which act as nano-bullets when microwave heated in a solution. We observed that the size and number of the uric acid crystals were reduced by >60% within 10 minutes of low power microwave heating. In addition, the use of gold colloids without microwave heating (i.e. control experiment) did not result in the de-crystallization of the uric acid crystals, which proves the utility of our MAMAD technique in the de-crystallization of uric acid.

Cancer treatment methods using thermotherapy and/or enhanced immunotherapy are disclosed herein. One two-stage cancer treatment method comprises the steps of: (i) in a first stage, administering, to a patient with a metastatic malignancy, tumor-antibody-coated nanoparticles conjugated with one or more medications and/or one or more immune stimulators for attaching to circulating exosomes, extracellular vesicles, and/or circulating tumor cells, thus promoting a destruction of the circulating exosomes, extracellular vesicles, and/or circulating tumor cells by a cellular immune system of the patient; and (ii) in a second stage, treating a main tumor of the patient during the same session or during another session of therapy by administering the tumor-antibody-coated nanoparticles conjugated with the one or more medications and/or the one or more immune stimulators so as to stimulate the cellular immune response of the patient to destroy the main tumor.

The current invention concerns systems, devices and methods for the ablation of a vessel's wall from the inside, more specifically to implant devices and to the ablation of the wall of one or more pulmonary veins (PV) from the inside, preferably transmural ablation and preferably at the level of the antrum. Hereby, one or more implant devices can be implanted in the vessels and can subsequently be heated by external energy-providing means.

A method of killing cells of a targeted cell type in a patient body that utilizes nanoparticles having a first portion, which when exposed to a target portion of a targeted cell type, binds to the target portion and a second portion, joined to the first portion, and comprised of a low resistivity material. The nanoparticles are introduced into a contact area where they contact cells of the targeted cell type. Contemporaneously, the contact area is exposed to a varying magnetic field of insufficient strength to increase the temperature of any part of the patient body by more than ten degrees Celsius, but which creates a current at the nanoparticles sufficient to disrupt function of the targeted cell type.

Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue. The AMF pulse treatment can be combined with an antibacterial/antimicrobial treatment regimen to reduce the time and/or antibacterial dosage amount needed to remove the biofilm from the metallic implant.