Some embodiments of the invention relate to a method of treating pulmonary hypertension comprising: introducing a catheter device comprising one or more energy emitting transceivers into the pulmonary artery lumen; positioning the one or more transceivers within the left, right and/or main pulmonary artery at a location which is in between the first bifurcation of the left pulmonary artery and the first bifurcation of the right pulmonary artery; and thermally damaging nerve tissue by emitting energy having parameters selected to damage nerves only within a distance window of between 0.2 mm and 20 mm from the intimal aspect of the pulmonary artery wall when the one or more transceivers are positioned at the selected location.

An illumination system is provided that includes a laser light source and an optical waveguide connected to and/or associated with the laser light source at a proximal end thereof. The illumination system includes a diffuser element at the distal end of the optical waveguide with a longitudinal axis extending perpendicular to the coupling surface of the optical waveguide into the diffuser element. The diffuser element emits light over its active length laterally of the longitudinal axis and has at a base body with a scattering element. The scattering element is aligned along the longitudinal axis substantially parallel or at an angle thereto. An emission intensity homogenizer along the longitudinal axis is provided. The illumination system exhibits an intensity distribution of lateral emission deviating by at most 50% from an average lateral emission intensity.

System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

A vascular optical fiber guidewire includes an optical fiber guidewire and a plug connected to the optical fiber guidewire. The plug may be a memory alloy plug including a handle, a fixing groove and a sleeve which are sequentially connected. A radius of a segment of the fixing groove is larger than a radius of a segment of the fixing groove. The fixing groove cooperates with an external connector to provide a locking effect. The sleeve is provided with an elastically deformable spiral structure. The memory alloy plug is sleeved on a metal tube sleeved outside the optical fiber guidewire and connected with the optical fiber guidewire. A part of the metal tube extending from the memory alloy plug forms a spiral shape by spirally cutting to protect and support the optical fiber guidewire. The insertion and extraction operations and rotating operations can be facilitated.

A treatment method is disclosed capable of reducing the burden on a patient and enhancing the effect of killing tumor cells. A treatment method for killing a tumor cell, the method including inserting a catheter into a main artery of an organ having the tumor cell, administering an antibody-photosensitive substance into a vein before the inserting of the catheter, inserting an optical fiber into the catheter, reducing an influence of blood in the artery on a near-infrared ray, irradiating at least one of a tumor, the vicinity of the tumor, or a regional lymph node with a first near-infrared ray by the optical fiber, and irradiating an antibody-photosensitive substance bound to a tumor cell membrane in the tumor cell with a second near-infrared ray having a shorter wavelength than that of the first near-infrared ray.

The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

A medical device assembly is provided for removable insertion into a catheter with a lumen. The medical device assembly comprises an electromagnetic radiation (EMR) source for providing non-ultraviolet, therapeutic EMR having an intensity sufficient to inactivate one or more infectious agents and/or to stimulate healthy cell growth causing a healing effect, and a removable EMR conduction system at least partially insertable into and removable from the lumen of the catheter. The EMR conduction system has at least one optical element providing axial propagation of the therapeutic EMR through an insertable elongate body. The elongate body may have an exterior surface between a coupling end and a distal end tip that has at least one modified portion permitting the radial emission of therapeutic EMR from the elongate body proximate the modified portion. Such modified portion may be gradient along the exterior surface.

A system to be used to treat Leukemia, comprises a device to power, control and monitor an ultraviolet radiation as well as to monitor a blood contactless conductivity; and a catheter assembly with an inner dialysis catheter, an ultraviolet radiation source and a differential coil sensor. The system is using wavelengths of ultraviolet radiation to destroy infectious microbes that are in the blood and that are inside circulating tumor cells directly and indirectly as well as to destroy infectious microbes at primary tumor location (bone marrow). This is done without withdrawing the blood out of the body. Furthermore, the system measures a blood conductivity to evaluate the treatment process in a real time during the operation.

A blood vessel optical fiber guide wire includes at least one of optical fiber core wire, a wire wrapping layer and a hydrophilic coating capable of improving compatibility with body liquids and reducing the resistance. The optical fiber core wire is disposed in a core of the optical fiber guide wire. The wire wrapping layer is formed from at least one of winding wire or winding sheet wrapping outside of the optical fiber core wire. The hydrophilic coating is coated outside of the wire wrapping layer. The optical fiber guide wire may enter a predetermined position in artery blood vessel of human body. The light can be guided into and/or guided out of a location of lesion so as to achieve the photodynamic treatment of diseases such as tumor in vivo. The need to diagnosis and treatment in the field including biology and medical treatment can be met.

Methods and apparatuses for immunosuppression and/or immunomodulation for the treatment of an improper immune response with the use of UV light. In particular, described herein are methods and apparatuses for the treatment of inflammatory disorders using UVB light at appropriate intensities, durations and (internal) body regions in order to effect substantial and reliably treatment.