Systems and methods for illumination of a vascular space and its contents using an electromagnetic energy source that supplies a plurality of wavelengths ranging from ultraviolet to infrared are shown. Illumination can be performed using multiple wavelengths, simultaneously or sequentially, and can be performed in accordance with a protocol where an initial illumination produces an effect that is at least partially reversed by a subsequent illumination. Illumination protocols can be stored on a database and accessed via a user interface displayed on the electromagnetic energy source. The database can be used to store data related to performance of system components, and such data can be used to override or modify an illumination protocol.

A light irradiation device having an elongated outer shape includes: an optical fiber for emitting light from its distal end, which has a curved part, in which the distal end is oriented in a direction intersecting with a longitudinal direction of the light irradiation device by the curved part; and a light transmitting holder that retains a shape of the curved part of the optical fiber. The optical fiber has a core, or has the core and an outer surface layer, and the holder has a refractive index smaller than a refractive index of the core or a refractive index of the outer surface layer of the optical fiber.

An ultraviolet irradiation (UBI) device is configured to simultaneously irradiate blood flowing through a flat quartz crystal cuvette with both UV-A and UV-C light, wherein UV-A and UV-C lamps are positioned on opposite sides of the cuvette and calibrated to produce a two point source interference pattern having constructive interference points and maximum light intensity within the flow-through cuvette. Treatment of a cancer, an infectious disease or an autoimmune disease in a patient comprises simultaneously irradiating the blood with UV-A and UV-C light as it flows through the cuvette of the UBI device and into the vasculature of the patient.

A treatment method and a treatment system capable of effectively irradiating an antibody-photosensitive substance bound to a tumor cell with a near-infrared ray. The treatment method includes: intravenously administering the antibody-photosensitive substance; inserting a guide wire and a catheter into a main artery of an organ having the tumor cell; removing the guide wire; inserting an optical fiber into the catheter and advancing the optical fiber to a target position while checking a position of the optical fiber with an orientation marker disposed on the optical fiber; and irradiating the antibody-photosensitive substance bound to a tumor cell membrane with the near-infrared ray from the optical fiber while reducing an influence of blood in the artery on the near-infrared ray after 12 hours to 36 hours from intravenous administration.

In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

A device includes an angiography module, a phototherapy module, a carrier including an optical filter and accommodating the angiography module and the phototherapy module, and a control unit controlling operation of the angiography module and the phototherapy module. The angiography module includes infrared LEDs emitting infrared light through the optical filter to irradiate a limb of a subject, and an infrared sensor sensing a part of the infrared light reflected off the limb to generate a result, based on which the control unit generates an angiogram. The phototherapy module emits infrared light through the optical filter to irradiate the limb for phototherapy.

The present invention relates to an apparatus (1) for use in irradiation therapy, comprising an ionization module (2) adapted to emit ionization irradiation, and a power source (4) and a control unit (5) to provide a user interface. The apparatus is characterized in that the apparatus comprises an UV module (3) adapted to emit UVA, UVB and/or UVC irradiation (9), whereby the ionization module and the UV module emit irradiation simultaneously or alternately, and the ionization module emits irradiation (8) at a wave length at least below 100 nm. The invention also relates to a use of the apparatus for radiating an object (7) and use of the apparatus and method for treatment of a mammal (7). A detector may measure and/or create an image of the irradiation (6).

Medical devices and methods for making and using medical devices are disclosed. An example device may include an elongate shaft having a distal end region. An expandable framework may be disposed adjacent to the distal end region. An ultraviolet light-emitting member may be disposed within the expandable framework. A covering may be disposed along an outer surface of the expandable framework.

A catheter includes a long tubular main body, a window on a side of the main body and transmits light in a predetermined outward direction, and an opening on the side of the main body, the opening being configured to release a fluid. A direction in which the fluid is released from the opening intersects the predetermined outward direction in which light is emitted from the window.