Described embodiments are directed to a device for delivery of activatable compounds to a patients lumen, such as in transcatheter procedures. More specifically, described embodiments are directed toward delivery devices operable to deliver the activatable compounds and to activate the compounds by light. Such delivery devices include a balloon (14) having a treatment zone (16) for activatable compound delivery and/or activation and non-treatment zones (18) that block activatable compound delivery and/or activation for controlled delivery and activation of the activatable compounds.

Devices and methods for treating central nervous system disorders by administering light to a user are disclosed. In some embodiments, the devices are positioned away from the user, and in other embodiments, the devices are attached to the user. In some embodiments, the light is applied through the users skin, and in other embodiments, through an implanted or percutaneous device. Representative central nervous system disorders include cognitive, motor, and behavioral disorders. Where these disorders include an inflammatory component, light is administered at wavelengths which decrease inflammation in the brain. Where these disorders are caused by poor vascularization, light is administered at wavelengths which improve vascularization in the brain. The methods also include repairing damage to the blood brain barrier, and can be used to more effectively administer drugs, such as anticancer drugs, to the brain.

A light irradiating medical device comprising: a shaft extending in a longitudinal axis direction thereof and having a lumen extending in the longitudinal axis direction; a first tubular member disposed in the lumen of the shaft and rotatable about a rotation axis parallel to the longitudinal axis direction of the shaft, the first tubular member having a window located in a part of a peripheral wall of a distal portion; and a light guiding tool disposed in a lumen of the first tubular member and movable in the longitudinal axis direction, the light guiding tool including an optical fiber extending in the longitudinal axis direction, the optical fiber including a core, a cladding coating a radially outer portion of the core, and a cladding-absent portion located at a part of a distal portion of the core, and the window allowing passage therethrough of output light from the light guiding tool.

Disclosed herein is a therapeutically active agent usable in the treatment of pulmonary arterial hypertension (PAH), for use in the treatment of pulmonary arterial hypertension, as well as methods of treating PAH, said treatment and methods comprising administering such an active agent and effecting pulmonary artery denervation in the subject. In some aspects, a sub-therapeutically effective amount of the active agent is administered. In some aspects, the method is devoid of administering such an active agent for at least one month subsequent to the denervation. Further disclosed is a method of treating PAH comprising determining a responsiveness of the subject to at least one therapeutically active agent usable in treating PAH; and effecting pulmonary artery denervation in a subject responsive to the active agent(s).

An illumination system is provided that includes a laser light source, a light guide, a connector, and an emission element. The laser light source has a numerical aperture. The light guide has a proximal end and a distal end. The connector has a connector housing and connects and/or assigns the laser light source at the proximal end. The emission element is at the distal end. The connector housing has a device that reduce an influence of a range of variation of the numerical aperture so that an emission behaviour of the emission element is independent of a range of variation of the numerical aperture.

An implant sized and shaped to be endovascularly delivered to the middle meningeal artery includes a carrier that carries a payload between first and second ends thereof. An anchor mechanism associated with the implant transitions into a swollen state in response to exposure to bodily fluids. In the swollen state, said anchor mechanism anchors the implant to the middle meningeal artery. Before or during the transition, the anchor mechanism permits endovascular delivery of the implant to the middle meningeal artery.

An optical fiber guidewire according to an embodiment of the present disclosure includes at least one optical fiber and a sleeve surrounding the optical fiber. The sleeve includes a functional section, a guiding section and a supporting section that are connected in sequence. An asymmetric structure is provided on the sleeve itself or the surround of the sleeve along the optical fiber. Therefore, the optical fiber guidewire provided in this disclosure has good bending performance and operability, and thus can be easily manipulated, readily enters a body cavity with a larger opening angle, and achieves self-guidance and flexible detection of the optical fiber guidewire in the body cavity, thereby improving the effect of minimally invasive interventional treatment.

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

An optical fiber guidewire according to an embodiment of the present disclosure includes at least one optical fiber and a sleeve surrounding the optical fiber. The sleeve includes a functional section, a guiding section and a supporting section that are connected in sequence. An asymmetric structure is provided on the sleeve itself or the surround of the sleeve along the optical fiber. Therefore, the optical fiber guidewire provided in this disclosure has good bending performance and operability, and thus can be easily manipulated, readily enters a body cavity with a larger opening angle, and achieves self-guidance and flexible detection of the optical fiber guidewire in the body cavity, thereby improving the effect of minimally invasive interventional treatment.

A light irradiation medical device comprising: a shaft having a lumen extending in the longitudinal direction; and a light guiding device that is disposed in the lumen of the shaft and is movable in the longitudinal direction. The light guiding device extends in the longitudinal direction and has a light diffusion part at a distal part of the light guiding device. The shaft has: a first window in a peripheral wall of a distal part of the shaft; and a second window at a distal end face of the shaft. The shaft has a reflection surface inside the shaft and at a distal side with respect to the first window, and reflects light emitted from the light guiding device.