A light-emitting diode (LED) therapy device and method of use is provided that increases healing of tissues by targeting damaged tissue at a predetermined wavelength and pulsed at a predetermined frequency. The device includes a housing and a light radiation module enclosed within the housing. The light radiation module includes an LED, a controller unit connected to the LED to control wavelength and pulsed frequency of the LED, and a rechargeable power source. The device also includes a light-diffusing member connected to the housing designed to diffuse light emitted from the LED to damaged tissue in a human cavity. Light in the red or near infrared range and pulsed at a Nogier frequency increases the effectiveness of the LED device to stimulate healing of damaged tissues. Particular devices include incorporation into a pacifier for healing an infant's gums, or nasal, auditory, vaginal, or anal cavities and adults or children.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

Light-based systems and methods are provided with targeted antibacterial action for mouth care in animals such as dogs. In various embodiments, the device includes a substantially impermeable shell. The shell has an outer surface. The outer surface has at least one substantially transparent region. The device further includes at least one light-emitting diode disposed within the shell. The at least one light-emitting diode is adapted to emit light having a wavelength between about 400 nm and about 1,000 nm when powered. The at least one light-emitting diode is configured to provide an average light intensity of between about 10 and about 50 mW/cm.sup.2 across the at least one substantially transparent region of the outer surface. The device further includes a power source disposed within the shell. The device further includes a switch at least partially disposed within the shell and adapted to control current flow from the power source to the at least one light-emitting diode.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

An oral appliance for treating sleep apnea in a user includes a mouthpiece configured for being positioned in an oral cavity of the user, and at least one pulse oximeter attached to the mouthpiece. According to an aspect, the pulse oximeter is configured to monitor actual oxygen saturation levels of hemoglobin of the user when the oral appliance is positioned in the oral cavity of the user. The oral appliance may include an additional sensor attached to the mouthpiece that includes at least one of an airflow sensor, a pressure sensor, a noise detector, and an actigraphy sensor.

In some embodiments, an apparatus comprises a housing, an emitter, and an electronic circuit. The housing is configured to fit within a patient's mouth. The emitter is at least partially encased within the housing. The emitter is configured to emit an effective amount of light to the alveolar soft tissue when the housing is disposed within the mouth. The electronic circuit is operatively coupled to the emitter. The electronic circuit is configured to control the emitter when the housing is disposed within the mouth and the apparatus is in use during orthodontic treatment. The apparatus and its use for regulating tooth movement or maintaining or improving oral tissue health are disclosed herein.

A diode laser system having high-power diode(s) said high-power diode(s) producing laser outputs in a range of 0.1 to 25 Watts of power using optimum wavelengths via a single optical delivery fiber.

The present disclosure relates to a phototherapy device that can deliver light to tissues to activate photoactive agents that have been applied to the tissues or that are included within a fiber optic tip member of the device which may be coupled to a light source using a sleeve. The present disclosure also relates to methods of phototherapy using the phototherapy device such as anti-bactericidal treatment, anti-fungal treatment, anti-parasitic treatment, anti-viral treatment.

An ampoule with an integrated piezoelectric unit for use with a personal nebulizer or vaporizing unit with a mouthpiece. The substance to be vaporized is contained in the ampoule which is inserted into the unit, where the substance is vaporized through the integrated piezoelectric transducers or atomizers providing sonic or ultrasonic vibration. The substance to be vaporized may include a variety of therapeutic, homeopathic, or naturopathic formulations, remedies, or serums.

A multi-phase oral composition and electromagnetic radiation source for whitening teeth.