Methods of treating skin disorders are disclosed. The methods involve impinging light having a first peak wavelength on the tissue at a first radiant flux, wherein the first peak wavelength and the first radiant flux is selected to provide an anti-inflammatory effect, and impinging light having a second peak wavelength on the tissue at a second radiant flux, wherein the second peak wavelength and the second radiant flux are selected to either stimulate enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide or release nitric oxide from the endogenous stores are disclosed. Representative skin disorders include pruritus, psoriasis, acne, rosacea, and eczema, and the skin can include the scalp. The methods can reduce stinging and/or itching associated with the skin disorder. The anti-inflammatory wavelengths can be in the range of between about 650 and about 680 nm.

This disclosure relates generally to medical devices, systems, and methods for activation of a photoactive agent during a medical procedure. In an aspect, a catheter system for activation of a photoactive agent may comprise a catheter comprising an elongate shaft comprising a proximal portion, a distal portion, and a first lumen extending along the elongate shaft. A first flexible circuit may be disposed about the distal portion of the elongate shaft. A plurality of first light-emitting diodes (LEDs) may be disposed along the first flexible circuit. A second flexible circuit may be disposed about the distal portion of the elongate shaft. A plurality of second LEDs may be disposed along the second flexible circuit. A control unit may be coupled to the proximal end of the elongate shaft. The communications cable may be disposed within the catheter and may electrically couple the first LEDs with the control unit.

A device and method for therapeutically treating conditions using electromagnetic radiation (EMR) is described herein. EMR, of optimal wavelengths and at surprisingly low energy levels, are pulsed for a time duration when aimed at an area of interest, the outcome being an improvement in the condition while not doing damage to surrounding tissue.

A treatment method is disclosed capable of reducing the burden on a patient and enhancing the effect of killing tumor cells. The method includes administering an antibody-photosensitive substance into a vein; inserting an endoscope from a mouth, a nose, or an anus and bringing the endoscope to a vicinity of a tumor after the administering of the antibody-photosensitive substance into the vein; placing an optical fiber into the tumor or in the vicinity of the tumor; irradiating at least one of the tumor, the vicinity of the tumor, or a regional lymph node with a first near-infrared ray by the optical fiber; and irradiating the antibody-photosensitive substance bound to a tumor cell membrane in the tumor cell with a second near-infrared ray after the irradiating with the first near-infrared ray, the second near-infrared ray having a shorter wavelength than that of the first near-infrared ray.

A hand-held light treatment device configured with interchangeable emitter heads that are pre-programmed with desired treatment protocols and updated from a remote store of treatment protocols. The removable emitter heads each contain one or more treatment LEDs, a tracking light, a task light, a proximity sensor, and a control module. A tip is attached to the emitter head, either removably or integral therewith. In in one embodiment, the tip is integral with the emitter head and emits light perpendicular to the handle. Some embodiments have tips of various shapes that attach to the emitter heads, which permits a single device to direct the emitted energy at nearly any direction. The tips can be disposable or reusable. The light-emitting device may be used in conjunction with distilled water to treat infections, sterilize wounds or to minimize infection prior to surgical closure.

A device for providing fractional treatment of a body orifice includes a source of fractionated energy and a source of electrical muscle (EMS) energy. A programmed controller controls the application of fractionated and/or EMS energy. A probe is inserted by its distal end into the body orifice. The source of fractionated energy is positioned for transmitting fractionated energy from the source of fractionated energy through the probe to tissue in the vicinity around the body orifice; and, the source of EMS is positioned for transmitting EMS energy from the source of EMS energy through the probe to tissue in the vicinity around the body orifice. The programmed controller is configured to control the activation of fractionated energy and EMS energy one of simultaneously or sequentially.

An aqueous solution for intraoral cleaning via irradiation with ultraviolet ray and/or near-ultraviolet visible ray and/or ray in an 800-900 nm near-infrared region is employed as the hydrogen peroxide aqueous solution, wherein a concentration of hydrogen peroxide is 1 w/v % to 7 w/v %, and a concentration of a hydrogen peroxide stabilizer is 81 ppm (mg/L) or less in the aqueous solution.

A device including a semi-rigid shell forming an external surface with at least part of the shell adapted to contact tissue of a body cavity. The shell includes a treatment band formed around the shell, a first portion forming a rounded end of the device that is distal to the treatment band, and a second portion formed around the circumference of the shell and located proximal to the treatment band. The device further includes a vibration mechanism configured to case the shell to vibrate, a sensor configured to provide sensor data upon contact with the tissue, and a processor configured to receive the sensor data and to use the sensor data to produce parameters of the tissue.

An external auditory canal therapy device may include a housing inserted into an external auditory canal of a human ear, at least one electrically conductive electrode coupled to the housing and one or both of at least one irradiation source and at least one speaker coupled to the housing. An electrical circuit carried by the housing may control the at least one electrically conductive electrode to provide electrically stimulation through the dermis to at least one of an arterial branch and a peripheral nerve branch of at least one cranial nerve, and may control one or both of the at least one irradiation source to irradiate the at least one of the arterial branch and the peripheral nerve branch of the at least one cranial nerve through the dermis and the at least one speaker to produce acoustic waves directed toward a tympanic membrane of the ear.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.