A platinum(IV) complex has the structure of Formula I.

##STR00001##

where X, X′, Y, Y′, and Z are each independently an electron donor ligand, R.sub.1˜R.sub.5 are each independently a functional group, L is the linker unit, and n is selected from the group of 0, a positive charge, and a negative charge. Various methods contain steps for manufacturing the platinum(IV) complex, for treating cancer, a tumor, or an infection in a subject with the platinum(IV) complex. A pharmaceutical composition contains the platinum(IV) complex.

A method of treating CTCL comprising applying a combination of an effective amount of hypericin together with a form of visible light photodynamic therapy. Preferably, the effective amount of hypericin is an ointment comprising less than 1% hypericin. More preferably, the form of photodynamic therapy comprises an administration of escalating doses of visible light. Optionally, the escalating doses of visible light starts at about 5 J/cm.sup.2 and increases to a maximum dose of about 12 J/cm.sup.2.

The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.

This current disclosure is directed to charge-transfer heptamethine dyes for NIR singlet oxygen generation, each such dye comprising a near-infrared (NIR) absorbing dye having heptamethine linkages orthogonally coupled to an optionally substituted cationic heteroaryl ring moiety as a charge-transfer partner and uses thereof.

Provided are a treatment apparatus and a treatment method capable of effectively treating cancer tumor cell (for example cancer in a range including at least a part of a cervix). A treatment apparatus is configured to irradiate an antibody-photosensitive substance bound to a tumor cell with excitation light, and includes: a main shaft including a distal portion and a proximal portion; a distal structure portion disposed on a distal side of the main shaft and formed to be larger than the main shaft in a radial direction of the main shaft; a distal shaft protruding from the distal structure portion toward the distal side; and at least one irradiation unit configured to emit the excitation light of the antibody-photosensitive substance from the distal shaft and the distal structure portion.

A treatment apparatus and a treatment method capable of effectively treating cancer in a range including at least a part of a cervix. A treatment apparatus is configured to irradiate an antibody-photosensitive substance accumulated in a tumor cell with excitation light, and includes: a tubular device including an elongated tubular member; and an irradiation device configured to be inserted into the tubular member. The irradiation device includes a main shaft including a distal portion and a proximal portion, a disk portion disposed on a distal side of the main shaft, a distal shaft protruding from the disk portion toward the distal side, and an irradiation unit disposed on the distal shaft and configured to emit the excitation light.

Embodiments of an improved photodynamic therapy device are provided. An example of the device includes an irradiation head having a first end and a surface at a second end, the surface having a radius of curvature. The device also includes a plurality of light sources disposed on the curved surface. The plurality of light sources are configured to emit light having at least one wavelength corresponding approximately to an excitation peak of at least one photosensitizer. The light emitted by the plurality of light sources is focused to a focal point based on the radius of curvature of the surface and a target surface (e.g., a corneal surface of an eye) may be positioned at the focal point for treatment.

The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

An interoperative light therapy apparatus and method are disclosed. The apparatus includes an excitation light source, a plurality of light emitting devices and a plurality of light detecting fibers, wherein the plurality of light emitting devices produce a fluorescence light in cancerous cells of a patient treated with a photosensitizing medication. The fluorescence light is collected by the plurality of detector fibers and a digital spatial image of the cancerous cells is produced. The digital spatial image is useful for targeting the cancerous cells in a subsequent resection procedure. An interoperative light therapy apparatus is disclosed that further include a therapy light source that can deliver therapy light to the cancerous cells using the digital spatial image in the subsequent resection procedure.

A method for decomposing a compound represented by Formula (1) includes irradiating the compound with X-rays in a presence of an electron donor:

##STR00001##

wherein R.sup.111, R.sup.121, R.sup.131, and R.sup.141 each independently represent a monovalent organic group; p, q, r, and s each independently represent an integer of 0 or 1 to 4; in the case where two or more R.sup.111, R.sup.121, R.sup.131, and R.sup.141 are present, they may be identical to or different from one another or may be bonded to one another to form a ring; A.sup.101 represents a monovalent organic group; and A.sup.102 represents a hydrogen atom or a monovalent organic group). In the method, a photosensitive dye can be decomposed using an energy beam which can penetrate deeper into a living body than near-infrared light and activate the photosensitive dye.