Systems and methods for determining one or more temperatures within a phototherapy blanket use or include one or more temperature sensors and a set of light sources to determine a temperature of a subject undergoing phototherapy within the phototherapy blanket and estimate a core temperature of the subject based on, at least, the temperature. The phototherapy blanket may include a thicker region having a higher thermal insulation than one or more other regions of the phototherapy blanket. By virtue of measuring the temperature at or near the thicker region, the uncertainty in the relation between a temperature and the subject's core temperature may be reduced, for more accurate temperature determination within the phototherapy blanket.

A portable irradiation device is disclosed including: a hollow squeezing part operable to squeeze air therein out; a sucker having a first end opening portion and a second end opening portion, the first end opening portion being hermetically connected with the squeezing part, the second end opening portion being attachable to a human body by means of a difference in air pressure between inside and outside the sucker; and a blue light irradiation unit located in a space surrounded by the squeezing part, the sucker, or the squeezing part and the sucker. Also disclosed is a method for manufacturing a portable irradiation device.

Disclosed is a positioning device for use in a compound portable phototherapy device to contain and enhance therapeutic treatment to a subject. The positioning device comprises an inner surface composed of a non-porous, light reflective material, as well as an outer surface that may be opaque. Use of the positioning device in conjunction with a phototherapy device secures advantages of increased incident light directed on a subject and a controlled thermal environment for the subject. The positioning device may be portable and may be pliable, capable of being rolled or compressed. The positioning device may optionally include a visor, venting, and stabilizing cushioning. The positioning device may optionally include a thermal regulation element.

Some embodiments relate to methods of treating hyperbilirubinemia comprising administrating a therapeutic amount of a metalloporphyrin to an infant. Administration may occur when the infant's measured total serum bilirubin levels are at or below about the level suggested by the AAP nomogram for initiating phototherapy, when the infant's measured total serum bilirubin levels are at about the level suggested for initiating phototherapy in an infant, or when the infant's measured total serum bilirubin levels are at about the level suggested for initiating phototherapy. Administration may occur without regard to the total serum bilirubin level of the infant. In some embodiments, administration of the metalloporphyrin does not cause QT prolongation.

Compounds of formula (1) that have functional substituents in a specific spatial arrangement, and electronic devices that include a compound of formula (1), and to the preparation of compounds of formula (1). ##STR00001##

Methods of treating hyperbilrubinemia or reducing total serum bilirubin levels include initiating phototherapy on an infant while substantially simultaneously administering to the infant a therapeutic amount of stannsoporfin. Various embodiments are directed to treating hyperbilirubinemia and decreasing bilirubin levels.

Compounds of formula (1) that have functional substituents in a specific spatial arrangement, and electronic devices that include a compound of formula (1), and to the preparation of compounds of formula (1).

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A phototherapy device including a flexible light emitting pad is provided. The phototherapy device allows an infant to be swaddled while the infant simultaneously receives phototherapy treatment on his/her front, back, and sides without the use of external light sources.

An uneven affected area is uniformly irradiated with light. A photoirradiation device includes a flexible substrate, a plurality of LED chips arranged in a matrix over the flexible substrate, walls having flexibility and surrounding the plurality of LED chips, and a protective resin, formed within the walls so as to cover the plurality of LED chips, that has translucency to transmit emitted light emitted by the plurality of LED chips and has flexibility. The emitted light is radiated from a region surrounded by the walls.

Embodiments of a photoarray system are provided. In one embodiment, a photoarray system includes a lixel array comprising a plurality of lixels each supporting one or more radiation sources; a power source associated with the lixel array; and a control system associated with the power source and each of the radiation sources, the control system comprising a master processor-readable medium configured to store at least a portion of data that specifies at least one lixel illumination pattern, the control system further comprising master processing structure configured to regulate use of power individually by each of the radiation sources based on the at least one lixel illumination pattern.