A method for treating a disease, disorder, or condition in a subject in need thereof, by administering either or both of (i) at least one photoactivatable pharmaceutical agent, or (ii) a first plurality of energy-emitting particles, into the subject in a region of the disease, disorder, or condition, whereby the administering is performed through inhalation; and applying an applied electromagnetic energy to the subject, wherein the applied electromagnetic energy directly or indirectly activates the at least one photoactivatable pharmaceutical agent, when present, and wherein when the first plurality of energy-emitting particles is present, the first plurality of energy-emitting particles absorbs the applied energy and emits an emitted electromagnetic energy, wherein the emitted electromagnetic energy interacts directly with the region of the disease, disorder, or condition or activates the at least one photoactivatable pharmaceutical agent.

Described herein are methods, devices and systems for stimulating neural oscillations in the high gamma wave frequency, in particular to promote neuronal plasticity and removal of the perineuronal net. Such methods, devices and systems are useful for treating neuropsychiatric disorders such as schizophrenia and depression in a subject in need thereof.

An object of the present invention is to provide a chair-type phototherapy device that enables a patient to perform light irradiation accurately targeted at a treatment site in a seated position on a chair and consequently achieves effective phototherapy even when the treatment site is in the back region that the patient is unable to see, for example, as in light irradiation for dysuria patients and patients with pain, and the patient performs light irradiation by himself/herself at home. The present invention provides a chair-type phototherapy device having a seat on which a patient is seated. The chair-type phototherapy device includes a radiation module configured to emit radiation light toward a living body, a drive module positioned behind the patient for moving the radiation module, and a fixing module fixing the drive module to the seat.

A method facilitates altering consciousness by transcranial stimulation to adjust the membrane potential duration of sensory cortex dendritic spine necks. Sensory cortex spine neck membranes are conscious. The method comprises the steps of placing electrodes on or near a scalp; applying electric fields to spine neck membranes in sensory cortex; adjusting stimulation parameters; and altering consciousness for a predetermined duration.

An optical stimulation lead includes a lead body including a distal end, a distal portion, and a proximal portion; and an optical assembly attached to the distal end of the lead body. The optical assembly includes a light emitter; a feedthrough assembly including at least one ceramic block, at least one feedthrough pin extending through the at least one ceramic block and electrically coupled to the light emitter, and a metal housing attached to the at least one ceramic block; a metal tube attached to the feedthrough assembly and disposed around the light emitter; and an emitter cover disposed over the light emitter and coupled to the metal tube.

Provided herein are methods of treating a patient comprising providing a medical apparatus comprising an external system and an implantable system, implanting the implantable system, and delivering at least one of power or data to the implantable system with the external system. The external system comprises: at least one external antenna configured to transmit a first transmission signal to the implantable system; an external transmitter configured to drive the at least one external antenna; an external power supply; and an external controller. The implantable system comprises: at least one implantable antenna configured to receive the first transmission signal from the first external device; an implantable receiver; at least one implantable functional element configured to interface with the patient; an implantable controller; an implantable energy storage assembly; and an implantable housing surrounding at least the implantable controller and the implantable receiver. Medical apparatus are also provided.

An optical stimulation system includes a light source configured to produce light for optical stimulation; a light monitor; an optical lead coupled, or coupleable, to the light source and the light monitor; and a control module coupled, or coupleable, to the light source and the light monitor. The control module includes a memory, and a processor coupled to the memory and configured for receiving a request for verification or measurement of a light output value; in response to the request, receiving, from the light monitor, a measurement of light generated by the light source; and, based on the measurement, reporting a response to the request.

An implantable medical system includes a light delivery module comprising a light source that generates light and a controller that controls the output of the light source, a lead with a plurality of electrodes, the lead extending from a proximal end to a distal end, wherein the lead further comprises an optical light guide configured to deliver the light from the light source, and the controller is configured to deliver voltage across two or more of the electrodes to steer a distal end of the optical light guide, to provide electrical stimulation or sense/record electrical signals.

An external auditory canal therapy device may include a housing inserted into an external auditory canal of a human ear, at least one electrically conductive electrode coupled to the housing and one or both of at least one irradiation source and at least one speaker coupled to the housing. An electrical circuit carried by the housing may control the at least one electrically conductive electrode to provide electrically stimulation through the dermis to at least one of an arterial branch and a peripheral nerve branch of at least one cranial nerve, and may control one or both of the at least one irradiation source to irradiate the at least one of the arterial branch and the peripheral nerve branch of the at least one cranial nerve through the dermis and the at least one speaker to produce acoustic waves directed toward a tympanic membrane of the ear.

The invention provides an IPG and lead configuration which boasts both a novel optical folding assembly and an optical processor assembly which offers the advantages of low heat generation and compact package size. The surgical leads provided offer additional advantages over the prior art including integral formation of optical and electrical components in a compact size. The invention further provides processing advantages which measure and compensate for degradation in the optical system over time.