Disclosed herein is a multiple light emitter device which inactivates microorganisms. The device includes at least two light emitters and at least one light-converting material arranged to convert at least a portion of light from the light emitters. Any unconverted light emitted from the light emitters and converted light emitted from the at least one light-converting material mixes to form a combined light, the combined light being white. In one aspect, the light emitters include at least one blue light emitter and at least one violet light emitter. In another aspect, the light emitters include one blue light emitter and one emitter within the range of approximately yellow to infrared light.

The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

A method of providing doses of light sufficient to deactivate bacteria throughout a volumetric space. The method includes: (1) receiving data associated with a desired illuminance level for the space, indicative of an estimated occupancy of the volumetric space over a pre-determined period of time, and indicative of dimensions of the space; (2) determining, based on the received data, an arrangement of one or more lighting fixtures in the volumetric space, the one or more lighting fixtures configured to at least partially emit disinfecting light having a wavelength of between 400 nm and 420 nm, and a total radiometric power to be applied via the one or more lighting fixtures to produce a desired power density at any exposed surface within the volumetric space during the period of time; and (3) installing the determined arrangement of one or more lighting fixtures in the volumetric space.

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

Periodontal disorders such as disorders associated with a dental implant are treated with a laser where an average laser power along with other laser parameters provide particular settings for the treatment, the treatment including one or more of creating a gingival trough or flap around the implant, ablating or denaturing infected tissue via photothermolysis, lasing a pocket around the affected implant, and compressing marginal tissues against the implant.

A light radiation device includes a housing, a substrate provided in the housing, and a light source mounted on the substrate. The light source includes a first light source including at least one first light source to emit first light having a blue wavelength band, a second light source including at least one second light source to emit second light having a ultraviolet wavelength band, and a control unit to control the first light source and the second light source such that the second light source sequentially emits the second light after the first light source emits the first light. A dose of the second light source is less than 1/10 of a dose of the first light source.

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.

A device including a semi-rigid shell forming an external surface with at least part of the shell adapted to contact tissue of a body cavity. The shell includes a treatment band formed around the shell, a first portion forming a rounded end of the device that is distal to the treatment band, and a second portion formed around the circumference of the shell and located proximal to the treatment band. The device further includes a vibration mechanism configured to case the shell to vibrate, a sensor configured to provide sensor data upon contact with the tissue, and a processor configured to receive the sensor data and to use the sensor data to produce parameters of the tissue.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device comprises a tissue penetrating member having a distal end and a proximal end, the tissue penetrating member configured to penetrate the tissue of the patient to be inserted into the tissue, wherein the tissue penetrating member is at least partially optically transparent along a surface of the tissue penetrating member positioned between the distal end of the tissue penetrating member and the proximal end of the tissue penetrating member to provide optical transmission of at least a portion of the light through the surface of the tissue penetrating member, thereby allowing at least the portion of the light to be delivered into the tissue of the patient when the tissue penetrating member is inserted into the tissue; and a substrate that supports the tissue penetrating member.