A system and method for interstitial photodynamic light therapy (I-PDT) of a tissue. A plurality of light-transmitting catheters (LTCs) are provided and placed in the tissue according to a pre-determined treatment plan, wherein an LTC includes a first treatment fiber disposed therethrough, and an LTC includes a dosimetry fiber disposed therethrough. A dose light is provided to the tissue by way of the first treatment fiber according to the pre-determined treatment plan. Light received at the dosimetry fiber is measured using a spectrometer in operable communication with the dosimetry fiber. One or more properties of a photosensitizer in the tissue are determined. The treatment plan is modified based on the properties of the photosensitizer, and an updated dose light is provided to the tissue by way of the first treatment fiber according to the modified treatment plan.

A stimulation device is provided, which provides light and sound stimuli capable of inducing the production of melatonin in a human individual subjected to said stimuli. Light and sound stimuli are produced by a light source and a sound emitter connected to a wearable mask or to a wearable frame. The desired stimulation can be easily adjusted by means of mobile devices. A method is also provided based on the stimulation device for optimizing the expression of melatonin in a patient subjected to a periodic and customized treatment. The device and method provide a physical well-being to the individual and are useful for enhancing the performance of athletes and for treating various diseases and symptoms related to low metabolic levels of the melatonin hormone.

The present disclosure is directed to a phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems methods. In one embodiment a phototherapeutic apparatus can include a housing at least partially defining an irradiation zone, and an ultraviolet (UV) radiation source carried by the housing. The irradiation zone can be configured to accommodate at least a portion of a human patient. The phototherapeutic apparatus can further include a filter between the UV radiation source and the irradiation zone. The filter can be configured to at least substantially remove UV radiation outside of a predetermined spectrum centered at about 297 nm and having a bandwidth of at most 10 nm.

A temperature sensor comprising a light emitter, an electrical circuit for applying a reverse bias voltage across the light emitter and for measuring a reverse current, and means for calculating a temperature from the measured reverse current.

An apparatus for biophotonic tissue treatments comprising a wearable light emitter device, suitable to be configured to be applied to a body portion to be submitted to treatment. The light emitter device comprising a closed chamber, light guides being formed at the inside in order to transfer a preset-frequency light radiation at pre-fixed treatment points of the device. The light guides are connected to at least an optical fibre that direct thereof the light generated by at least a light radiation source arranged in a control unit for controlling the emission of light radiation. The control unit is operated by an operation unit for managing the treatment and for monitoring its implementation thereof according to set up parameters. The light guides being formed during the same production process and with the same material as the light emitter device.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

The present specification discloses a photobiomodulation therapy garment having a garment structure configured to be worn by a user atop a skin surface with one or more near-infrared light sources integrated with the garment structure. The near-infrared light source is configured to emit near-infrared light directed to one or more regions of interest of the skin at a wavelength between 600 nm to 1600 nm and at a predetermined dosimetry and duration. A controller with a processor and memory is in communication with the near-infrared light source to control the operational parameters of the near-infrared light source.

An apparatus for obtaining an anti-tumour immunologic response by thermotherapy of a treatment lesion covering at least a portion of a tumour is disclosed. The apparatus comprises a heating probe comprising an optical fiber and a cooling catheter. The optical fiber is inserted in the cooling catheter. Further the heating probe has a light emitting area, and the heating probe is interstitially insertable into the tumour of the treatment lesion. The heat probe is internally cooled by a fluid circulating in said catheter. The apparatus further comprises a first thermal sensor member having at least one sensor area. The first thermal sensor member is positionable at a distance from said boundary. The apparatus also comprises a control unit for controlling a power output of said light source based on a measured first temperature.

A light therapy system includes a remote-control device and at least one light therapy device. Each light therapy devices include a main body, a plurality of optical emitters, a system controller and an onboard user interface device. The light therapy devices operate in a standalone mode using the onboard interface device and a cumulative mode where operating instructions are received from the remote-control device. The operating instructions are distinct and individual for each light therapy device, to permit identical or different operation between devices. The light therapy devices do not communicate directly with each other and are operated wirelessly by the remote-control device such that a failure in one light therapy device does not affect the operation of another light therapy device.

An apparatus for obtaining an anti-tumour immunologic response by thermotherapy of a treatment lesion covering at least a portion of a tumour is disclosed. The apparatus comprises a heating probe comprising an optical fiber and a cooling catheter. The optical fiber is inserted in the cooling catheter. Further the heating probe has a light emitting area, and the heating probe is interstitially insertable into the tumour of the treatment lesion. The heat probe is internally cooled by a fluid circulating in said catheter. The apparatus further comprises a first thermal sensor member having at least one sensor area. The first thermal sensor member is positionable at a distance from said boundary. The apparatus also comprises a control unit for controlling a power output of said light source based on a measured first temperature.