Systems and methods for adjusting a user's circadian rhythm are provided. In some embodiments, a system may be configured to obtain information relating to the user's present circadian rhythm and information relating to one or more anticipated times of sleep and/or wakefulness. The system may generate a model for estimating the user's circadian rhythm. The system may also generate a model for estimating the user's homeostatic sleep drive. Based on one or both models, the system may generate instructions for activating the light source to adjust the user's circadian rhythm.

A system including a thermal sensor with an instrument placed in a volume. The thermal sensor may be useful in determining a temperature at a surface of the instrument and a distance away from the instrument. A therapy may be performed based on a sensed temperature with the thermal sensors.

Dynamic dosing systems for phototherapy and associated devices, systems, and methods are disclosed herein. In some embodiments, a dynamic dosing phototherapy system can include a self-service phototherapy kiosk (“SPK”) configured to emit UV radiation, a user interface communicatively coupled to the SPK, and a dynamic dosing system communicatively coupled to the user interface and the SPK. The dynamic dosing system can determine initial, user-specific parameters specific to define a first individual phototherapy protocol, and then determine adjustments to the initial parameters and the first individual phototherapy protocol based on user inputs related to erythema response to a previous phototherapy treatment session. The SPK can deliver UV radiation to a user in accordance with the first individual phototherapy protocol and/or an adjusted, second phototherapy protocol that takes into account the user's erythema response.

Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus. Systems may receive sensed light values and automatically apply high- and/or low-CER illumination to effect the intended circadian phase.

A laser surgical apparatus for performing treatment by irradiating a part to be treated by a variable pulsed laser beam is disclosed. This apparatus includes a laser source which emits variable waveform output of treatment laser beam pulses; a flexible beam delivery for delivering the treatment laser beam emitted from the laser source, the flexible beam delivery includes at the distal end automated optical scanner comprising of 2 moving mirrors; and a surgical instrument is connected to an end of the scanner and used for irradiating the treatment laser beam delivered therein to the treatment part. By having the ability to vary the laser's output pulse frequency, pulse width, and pulse energy, multiple tissue effects can be achieved using one laser surgical apparatus.

Dermatological systems and methods for providing a therapeutic laser treatment wherein the magnitude of heat power or energy applied to a target skin area via a therapeutic laser pulse is based on the magnitude of cooling power or energy applied to the target skin area during a cooling of the skin prior to treatment with one or more therapeutic laser pulses.

This disclosure relates to a therapeutic crate system for housing an animal, the crate system comprising a crate housing including a top wall, a bottom wall located opposite the top wall, and side walls extending between the top wall and the bottom wall. In some embodiments, the therapeutic crate system comprises a sensor coupled to the crate housing, the sensor configured to determine a distance between the animal and the sensor. According to some embodiments, the therapeutic crate system comprises an energized panel coupled to a wall selected from the group consisting of the top wall, the bottom wall, and at least one of the side walls, and operatively coupled to the sensor, the energized panel configured to deliver a type of therapy selected from the group consisting of phototherapy, PEMF treatments, and sound therapy.

A system including a thermal sensor with an instrument placed in a volume. The thermal sensor may be useful in determining a temperature at a surface of the instrument and a distance away from the instrument. A therapy may be performed based on a sensed temperature with the thermal sensors.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include eyeglasses, a photodiode positioned to detect ambient light, light sources, and an input device. The system can include a neural stimulation system that retrieves a profile and selects a light pattern having a fixed parameter and a variable parameter. The neural stimulation system can set a value of the variable parameter of the light pattern, construct an output signal, and then provide the output signal to the light sources to direct light towards the fovea.

A method and system for determining an irradiation dose. The method for determining the irradiation dose includes determining a pixel having a biological feature in a region of interest in a radiotherapy simulated locating image by using a retrospective label; extracting a local radiomics feature based on the pixel having the biological feature, in which the local radiomics feature includes a grayscale histogram intensity, a tumor shape feature, a textural feature, a Laplacian of Gaussian filtering feature, and a wavelet feature; acquiring the local radiomics features to be measured; identifying a positive region having the local radiomics features to be measured based on the local radiomics features; performing three-dimensional reconstruction for the peripheral boundary of the positive region to determine a three-dimensional image.