Dermatological systems and methods for providing picosecond laser pulses at a plurality of treatment wavelengths, wherein at least one of the wavelengths is provided by an optical parametric oscillator (OPO) capable of providing picosecond laser pulses at a wavelength for treating one or more target tissue types such as a sebaceous gland, sebum, or collagen. In some embodiments, multiple OPOs may be provided to enable a wide range of selectable treatment wavelengths.

A method treating a root canal in a tooth by introducing into the pulp chamber of a tooth and pulsing a laser light into the fluid reservoir so as to disintegrate pulp within the root canal without generation of any significant heat in said liquid fluid so as to avoid elevating the temperature of any of the dentin, tooth, or other adjacent tissue more than about 5° C.

A method treating a root canal in a tooth by introducing into the pulp chamber of a tooth and pulsing a laser light into the fluid reservoir so as to disintegrate pulp within the root canal without generation of any significant heat in said liquid fluid so as to avoid elevating the temperature of any of the dentin, tooth, or other adjacent tissue more than about 5° C.

A method of delivering light energy to a pathological tissue includes emitting light energy from a first optical element within a cannula, producing a substantially uniform irradiance profile from the light energy within the cannula, transmitting the light energy emitted from the first optical element through a second optical element in thermal contact with a distal end of the cannula to the pathological tissue without ablating the pathological tissue, and conducting thermal energy from the pathological tissue through the second optical element and to the cannula.

The disclosure relates to a demethylation apparatus and a demethylation method wherein a terahertz wave of a first frequency band including a methylation resonance frequency is irradiated onto a methylated molecule to demethylate the methylated molecule, and to a cancer therapy apparatus including the demethylation apparatus and a cancer therapy method including the demethylation method.

The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).

A laser treatment apparatus that is configured to irradiate a laser beam to an affected area to treat the affected area. The laser treatment apparatus includes: a beam source device that is configured to output a laser beam; and a scanning device that is configured to scan a therapeutic range including the affected area with the laser beam by irradiating the laser beam to the therapeutic range. The scanning device has a transmission medium that is configured to change an output direction of a laser beam according to an applied voltage.

There is provided a phototherapy apparatus, in which the therapeutic light is delivered through one or more massage components. The massage component provides mechanical massage to the subject biological tissue and modifies the properties of the subject tissue in thickness, density, etc. to facilitate the absorption of the therapeutic light and enhance the effect of the phototherapy procedure. The light source of the phototherapy apparatus is actively cooled by a synthetic jet cooler.

Dermatological systems and methods for providing picosecond laser pulses at a plurality of treatment wavelengths, wherein at least one of the wavelengths is provided by an optical parametric oscillator (OPO) capable of providing picosecond laser pulses at a wavelength for treating one or more target tissue types such as a sebaceous gland, sebum, or collagen. In some embodiments, multiple OPOs may be provided to enable a wide range of selectable treatment wavelengths.

There is provided a phototherapy apparatus, in which the therapeutic light is delivered through one or more massage components. The massage component provides mechanical massage to the subject biological tissue and modifies the properties of the subject tissue in thickness, density, etc. to facilitate the absorption of the therapeutic light and enhance the effect of the phototherapy procedure. The light source of the phototherapy apparatus is actively cooled by a synthetic jet cooler.