An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

Multi-modal, portable, handheld devices for tissue assessment (e.g., wound assessment) are provided, as are methods of fabricating and methods of using the same. The devices can be used for virtual medicine (VM)-based wound management, such as VM-based diabetic foot triage (DFT) and management. The device can be used to take physiological measurements of temperature and/or tissue oxygenation of a wound to assess the wound, for example in a remote setting environment. The device can also be used to provide therapy for tissue repair and/or wound healing, apart from the multi-modal imaging of the tissue surface of the patient. For example, light therapy, such as low-level light therapy (LLLT) can be provided via one or more light emitting diodes (LEDs) and/or laser diodes.

A method, system and computer-readable medium of utilizing artificial lighting regulate a circadian clock of a human. By utilizing light emitting diodes (LEDs) that emit wavelengths associated with human opsin absorption spectra, a device may stimulate opsins in the human. For example, the device may replicate normal sunlight (e.g., based on season or time of day) by emitting light that changes in rhythmic intensity or spectral modulation.

Disclosed herein is a controlled drug release system of photoresponsive nanocarriers. Also provided are methods of making the nanocarriers. Also provided are method of using the nanocarriers for the treatment of diseases.

An ingestible gastrointestinal phototherapy device has a spherocylindrical body of non-digestible material having a cylindrical midsection and transparent light portals at ends thereof. The cylindrical midsection has control circuitry and a power source therein and each light portal is transparent and comprises an array of bioactive light source elements therein emitting bioactive light therefrom and being operably coupled to the control circuitry and power source.

The present invention relates to a system for corneal crosslinking of injured corneas, treating keratoconus, or correcting vision, the system comprising: a hyaluronic acid-dye conjugate; and a contact lens including an LED light source.

In the present invention, a dye is activated by receiving light irradiated from the LED light source of the contact lens so as to generate radicals, thereby generating a covalent bond between amino acid radicals of corneal collagen, and strengthening a collagen layer. In the present invention, the hyaluronic acid-dye conjugate, in which hyaluronic acid is bound to the dye, is used to improve penetration of the dye in the cornea, and the contact lens is used together with the hyaluronic acid-dye conjugate to further improve the penetration of the dye. In addition, the structure of the lens which presses the center of the cornea deforms the shape of the cornea, thereby having a vision correction effect.

A photobiomodulation system includes a) a control module having electronic subassembly disposed in a housing, a connector coupled to the housing and defining a connector lumen, and at least one light source to produce light in response to signals from the electronic subassembly; b) a lead coupled or coupleable to the control module and having a lead body defining a lead lumen and at least one opening along a distal portion of the lead, light emitters arranged along the distal portion of the lead, and optical fibers extending along the lead body and coupled to the light emitters; and c) a catheter assembly having a tube coupleable to a catheter pump, and a distal connector attached to the end of the tube and coupled or coupleable to the connector of the control module.

Respiratory function can be preserved and/or enhanced in patients with a respiratory insufficiency using a photoceutical applied by a photoceutical medical device to at least one primary inspiratory muscle and/or a lung. At least one site on a body of a patient can be selected for delivery of the photoceutical to the muscle(s); and the photoceutical can be applied at the at least one site by the photoceutical medical device for a time period from a first start time to a first end time to treat the at least one primary inspiratory muscle and/or the lung of the patient to preserve and/or enhance the respiratory function. The photoceutical can include a light signal with at least one delivery scheme (e.g., superpulsed, pulsed. and/or continuous) and one or more wavelengths.

A wearable photobiomodulation device comprises a shell portion and an illumination module and is configured to deliver light to a photoresponsive tissue of an individual. In some embodiments, the illumination module provides red and/or infrared light to a photoresponsive tissue on an individual at a dose of between about 5-50 mJ/cm.sup.2 over a target illumination area of about 100-200 cm.sup.2. Exemplary devices may be configured as a wearable sports cup with an integral or detachable illumination module that provides effective amounts of light to a target are to so effect photobiomodulation in an individual wearing the device.

Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.