Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.

An optical stimulation lead includes a lead body including a distal end, a distal portion, and a proximal portion; and an optical assembly attached to the distal end of the lead body. The optical assembly includes a light emitter; a feedthrough assembly including at least one ceramic block, at least one feedthrough pin extending through the at least one ceramic block and electrically coupled to the light emitter, and a metal housing attached to the at least one ceramic block; a metal tube attached to the feedthrough assembly and disposed around the light emitter; and an emitter cover disposed over the light emitter and coupled to the metal tube.

A phototherapy mask adapted to fit over the eye area of the user. The mask comprises a plurality of semiconductor light sources such as, but not limited to, light-emitting diodes (LEDs) or laser diodes, fiber optics, full spectrum light sources, RGB LEDs, piezo transducers, vibrational transducers (ultrasonic or otherwise), or a combination thereof, that provide therapeutic and rejuvenating effects to human tissue. The light sources are arranged so as to focus on the eye areas, and light enters through the eyes (open or closed). The light sources emit energy in the form of photons when switched on, which deliver energy to targeted tissue, penetrating the layers of skin and the eyes to produce a non-thermal photochemical effect at the cellular level.

A medical device assembly is provided for removable insertion into a catheter with a lumen. The medical device assembly comprises an electromagnetic radiation (EMR) source for providing non-ultraviolet, therapeutic EMR having an intensity sufficient to inactivate one or more infectious agents and/or to stimulate healthy cell growth causing a healing effect, and a removable EMR conduction system at least partially insertable into and removable from the lumen of the catheter. The EMR conduction system has at least one optical element providing axial propagation of the therapeutic EMR through an insertable elongate body. The elongate body may have an exterior surface between a coupling end and a distal end tip that has at least one modified portion permitting the radial emission of therapeutic EMR from the elongate body proximate the modified portion. Such modified portion may be gradient along the exterior surface.

A system and method of illuminating tissue, particularly within the cranial cavity, through the mouth or nose. The system includes a light source and a power source for powering the light source. Optics are included for directing light from the light source towards the cranial cavity when the apparatus is inserted into a cavity of the head. Light from the light source and output from the optic provides cellular interaction treatment toward a specified area of the head region. Providing illumination where there are already holes in the skull results in more efficient coupling of light to the cells.

The present invention is directed to enhanced methods of treating brain disorders, and devices suitable to implement these methods. In particular, the methods of treatment and related devices of the present invention utilize the coordinated application of negative suppressive stimulation of the brain hemisphere with the more negative valence in combination with transcranially applied light energy to the lateral forehead to activate the underlying cortex of the brain hemisphere with the more positive valence, e.g., synergistically. In addition, such methods and devices may be suitable to address co-morbid brain disorders (e.g., psychiatric disorder co-morbid with depression) in a more effective manner.

There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.

A facial beautifying and care apparatus includes a beauty bar (1) having an air supply passage (A), a negative pressure connecting hole (132), a conductive suction nozzle (15) and a first connection port (134); an EMS generation module (20) inside the beauty bar (1) electrically connected to the first connection port (134); an external negative pressure unit (6) separated from the beauty bar (1) and having a negative pressure driving control module (62) and a second connection port (637); the negative pressure driving control module (62) having an air supply tube assembly (66) with a negative pressure communicating hole (661); a communicating tube (7) communicating with the negative pressure connecting hole (132) and the negative pressure communicating hole (661); a conductive wire (8) connected to the first connecting port (134) and the second connecting port (637). Accordingly, the effects of facial skin firming, cleaning, beautifying and caring are achieved.

A phototherapy device includes a high intensity light source secured to a leaky light conducting fiber to leak light along the length of the fiber. The light fiber is illuminated at either or both ends by the light source and the light fiber is generally oriented in a 3-D spiral pattern to form a dome of light to provide phototherapy to an area of a patient's scalp to be treated. A generally hemispherical shell is formed of a first or inner translucent diffuser layer secured to a second or outer reflective layer, the first and second layers encapsulating the 3-D non-overlapping spiral pattern light fiber. A control system is also provided to turn off the light source when a break or discontinuity occurs in the fiber.

Systems and methods for developing and applying photosynthetic cellular substances to a human or animal for medical, therapeutic or cosmetic uses are provided. Photosynthetic cells, such as algal cells, can be used in these substances to provide the ability to continuously generate oxygen when exposed to a light source or other oxygen-generating trigger. The substances can be developed as a standalone liquid, gel or cream, or embedded within a bandage, mesh, scaffold or other structure with a light source to promote oxygen production. The substances can be applied topically for medical, therapeutic or cosmetic treatments, or injected internally for generation of oxygen within one or more parts of the body.