The present disclosure provides a combined Pulsed Electromagnetic Field (PEMF) therapy and Photobiomodulation (PBM) therapeutic device in the form of a flexible wearable that can be secured to a user's body part to apply targeted radiation to a desired area. The frequencies and pulse patterns of both types of radiation are controlled by a single controller of the device which can switch between a number of pre-set sequences and patterns. The device is wirelessly enabled to allow control via an external user device.

The invention is method comprising the use of an external photic stimulator treat and/or prevent pain in a subject, such as migraine headache, dental pain, and/or other sources of cranial pain. The presently disclosed method includes treating the pain externally through the cheek, over the zygomatic arch and area of the trigeminal ganglion. The external photic stimulation is believed to inhibit excessive firing of trigeminal ganglion circuits, preventing the excessive expression of calcitonin gene-related peptides and/or other inflammatory manifestations of the pain.

The present invention is directed to the use of gold nanoparticles to enable vision in the visually impaired. Retinal neurons remain functional despite photoreceptor degeneration. These neurons can be made light-sensitive to produce action potentials, by gold nanoparticles conjugated to high-avidity ligands for a variety of cellular targets. Once bound to a neuron, these particles transduce millisecond pulses of light into heat, which changes membrane capacitance, depolarizing the cell and eliciting action potentials. The technology described herein along with a camera and decoder can be used to aid the visually impaired by stimulating cells to send the appropriate messages to the visual cortex.

The present invention relates to a composition and a kit of parts for antimicrobial photodynamic therapy and uses of the same, the composition comprising (a) hydrogen peroxide, carbamide peroxide and/or sodium hypochlorite and (b) at least one photosensitizer capable of being activated by light emitted in the blue spectrum, in particular curcumin, riboflavin and erythrosine.

A laser irradiation device for performing treatment on human skin includes a casing that includes a grip part and a barrel part; a laser oscillator that is accommodated in the casing and configured to generate a laser beam to be irradiated through the barrel part; a contact sensor unit that includes electrodes exposed at the end of the barrel part and a contact sensing unit configured to sense an electric current flowing through the electrodes; and a skin treatment unit that is detachably connected to the barrel part and is operated based on electric signals transmitted through the electrodes of the contact sensor unit.

Systems are provided for compact implantable multi-site optical stimulation and/or combined electrical and optical stimulation of spinal cord, brain, dorsal root ganglion, peripheral nerve, or other tissue. High-power LEDs or other light-emitting elements are provided at the site of stimulation, avoiding complex fiber optics or other means for coupling light from a distant laser along a stimulator to target tissue. Colocation of electrical stimulation contacts and light emitters allows the same tissue to be stimulated electrically and optically, at the same time or according to an alternating or other pattern of combined electrical and optical stimulation. These stimulators can be used as part of permanently implanted systems and/or as part of temporary, percutaneous stimulator systems. Optical and/or combined electrical and optical stimulation can be provided for pain relief, to encourage wound healing in nervous or non-nervous tissue, or to provide other clinical benefits.

A transcranial stimulator includes a main body formed in a shape that covers part or all of a head surrounding a skull, a light emission module configured in the main body to transmit light energy to a brain, and a controller configured to control an operation of the light emission module, wherein the light emission module includes a first optical device emitting light in a wavelength band of 630 nm to 680 nm toward the skull and a second optical device emitting light in a wavelength band of 780 nm to 990 nm toward the skull.

A device and method for disinfecting and/or enhancing healing of a wound or surgical site facilitates placing a light-emitting device with a frame having a central void, the central void adapted to surround the wound or surgical site; an illumination source disposed on the frame for directing safe, therapeutic light centrally towards the underlying wound or surgical site; and the transparent central void enabling visualization and clinical monitoring of the underlying wound or surgical site.

A computer-based system for receiving, analyzing, processing, managing and sending personal health information, and other information in conjunction with use of one or more personal nebulizer or vaporizing devices and personal breath analysis devices. System devices include a personal nebulizer or vaporizing unit with a mouthpiece, which may be detachable and replaceable. The mouthpiece includes an orifice through which vapor is emitted. The substance to be vaporized is contained in an ampoule inserted into the device, where the substance enters an atomization chamber where vaporization is achieved through piezoelectric transducers or atomizers providing sonic or ultrasonic vibration. The substance includes a variety of therapeutic, homeopathic, or naturopathic formulations, remedies, or serums.

Disclosed is a structure for therapeutic applications comprising at least one layer with sensor elements and heating elements. A first force affects the layer from one side and a second force affects the layer from the other side. The forces are detectable. The sensor elements can comprise, for example, position sensors, pressure sensors, and temperature sensors.