A transcranial stimulator includes a main body formed in a shape that covers part or all of a head surrounding a skull, a light emission module configured in the main body to transmit light energy to a brain, and a controller configured to control an operation of the light emission module, wherein the light emission module includes a first optical device emitting light in a wavelength band of 630 nm to 680 nm toward the skull and a second optical device emitting light in a wavelength band of 780 nm to 990 nm toward the skull.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Provided is a skin care device including a head part brought into contact with skin of a user, a battery configured to supply power for operation of the head part, a body part having a fastening portion provided at one end to which the head part is fastened and provided with the battery therein, and a cap assembly detachably attached to one end of the body part and forming an accommodation space configured to accommodate the head part, wherein the cap assembly includes a sterilization module disposed to irradiate ultraviolet light toward the head part when the cap assembly accommodates the head part.

Provided herein are methods and systems for modulating temporal patterns of neuronal activity in the brain. A method of the present disclosure may include using optogenetics to stimulate a one or more of thalamocortical projections, thalamic relay neurons, cortical projection neurons, cell bodies in a thalamic submedial nucleus, and cell bodies in the VLO in the brain, in conjunction with fMRI of different regions of the brain to directly visualize the global influence of the VLO's afferent and efferent connections, and characterize how different temporal patterns of activity in the VLO circuit affect brain dynamics by driving its input and output at distinct frequencies.

Provided herein is a multifunctional aesthetic system including a housing, an electromagnetic array situated in the housing and having one or more electromagnetic radiation (EMR) sources, a controller in electronic communication with the array to operate the one or more of the EMR sources to direct the EMR beam to a treatment area, and one or more sensors in electronic communication with the controller for providing feedback to the controller based on defined parameters to allow the controller to adjust at least one operating condition of the multifunctional system in response to the feedback.

The present invention relates generally to a device for providing multi-modal energy therapy to treat neurogenerative disorders, and more particularly to a device providing multi-modal neuro-supportive energy therapy to a person via a daily session in a single facility. The device provides safe, well studied energy therapies in a controlled manner to stimulate neuronal mitochondrial activity which powers the brains neurons and is often defective in neurodegenerative disease states. Selected energy delivery mechanisms and frequencies are employed to stabilize microglial activity and promote microglial homeostasis and neuroprotective secretions, including mitochondrial melatonin and other neuroprotective factors. In addition to practicality, the combination of these proven therapeutic modalities into a single device may offer synergies not found when they are employed alone. This focused combination of these unique energy based therapies may offer new hope to slow, stop, reverse or mitigate neurogenerative disorders, such as Alzheimer's, ALS and Parkinson's diseases.

The present disclosure provides a method for treating ischemic stroke by illuminating a skin surface to reduce free radical generation in subsurface target tissues (e.g., the brain following an ischemic event). The method utilizes a waveguide that receives light from a light source. The waveguide is placed adjacent a skin surface of a patient and the waveguide emits light that passes through the skin surface and illuminates a subsurface target tissue. The waveguide includes light-extracting features configured to emit light at a target angle relative to the surface tissue. That is, the light-extracting features alter a trajectory of light emitted by the waveguide, such that a larger percentage of light emitted by the light guide has an angle that is +/−25 degrees off of a center line of the light guide.

Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

The technology disclosed herein relates to a transcutaneous irradiation device having a top portion and a bottom portion. The top portion may include one or more transcutaneous irradiation modules configured to be arranged on a head of a user, the top transcutaneous irradiation modules including a top pulsed laser source. The bottom portion may include one or more transcutaneous irradiation modules configured to be arranged on an abdomen of the user, the top transcutaneous irradiation modules including a bottom pulsed laser source. A modulation frequency may be applied to the top and bottom irradiation modules such that the top and bottom pulse laser sources are subjected to a double pulse.

An optical stimulation system includes a light source configured to produce light for optical stimulation; a light monitor; an optical lead coupled, or coupleable, to the light source and the light monitor; and a control module coupled, or coupleable, to the light source and the light monitor. The control module includes a memory, and a processor coupled to the memory and configured for receiving a request for verification or measurement of a light output value; in response to the request, receiving, from the light monitor, a measurement of light generated by the light source; and, based on the measurement, reporting a response to the request.