The present disclosure relates to systems, methods, and uses of systems for treating a skin condition with phototherapy. A system comprises (a) a phototherapy device comprising a phototherapy light source; (b) a patient computing device comprising a processor and a memory, the patient computing device configured to: transmit a first signal to the phototherapy device enabling operation of the phototherapy device according to one or more conditional prescription parameters, activate the phototherapy light source, and transmit a second signal reporting operation of the phototherapy device; and (c) a server configured to communicate with the patient computing device and receive the second signal.

The subject matter of the invention is a therapeutic device in the form of a cylindrical chamber which comprises a hyperbaric chamber, LED matrices (5) and inductive coil rings (10, 11, 12, 13), constructed in one inseparable set in the form of a chamber of 200-280 cm in length and diameter of the round cylinder (70-130 cm).

A ring has an open top side and side walls that circumscribe a central region for receiving a phototherapy subject. The side walls include a work surface that is configured to receive visible light through the open top side and reflect the visible light toward the central region for phototherapy. The work surface includes a first surface that is a diffuse reflector and a second surface that is a specular reflector.

A sterilizing mouthpiece assembly for reducing the airborne transmission of infectious diseases includes a mouthpiece for positioning in a user's mouth. A shelf is integrated into the mouthpiece and a wedge extends upwardly from the shelf. A plurality of first light emitters is each of the first light emitters is integrated into the mouthpiece and each of the first light emitters emitting light in the ultraviolet spectrum to sterilize the inside of the user's mouth. A plurality of second light emitters is each positioned on the wedge and each of the second light emitters emits light in the ultraviolet spectrum to sterilize the inside of the user's mouth.

A hand-held light treatment device configured with interchangeable emitter heads that are pre-programmed with desired treatment protocols and updated from a remote store of treatment protocols. The removable emitter heads each contain one or more treatment LEDs, a tracking light, a task light, a proximity sensor, and a control module. A tip is attached to the emitter head, either removably or integral therewith. In in one embodiment, the tip is integral with the emitter head and emits light perpendicular to the handle. Some embodiments have tips of various shapes that attach to the emitter heads, which permits a single device to direct the emitted energy at nearly any direction. The tips can be disposable or reusable. The light-emitting device may be used in conjunction with distilled water to treat infections, sterilize wounds or to minimize infection prior to surgical closure.

Disclosed herein is a multiple light emitter device which inactivates microorganisms. The device includes at least two light emitters and at least one light-converting material arranged to convert at least a portion of light from the light emitters. Any unconverted light emitted from the light emitters and converted light emitted from the at least one light-converting material mixes to form a combined light, the combined light being white. In one aspect, the light emitters include at least one blue light emitter and at least one violet light emitter. In another aspect, the light emitters include one blue light emitter and one emitter within the range of approximately yellow to infrared light.

A light radiation device includes a housing, a substrate provided in the housing, and a light source mounted on the substrate. The light source includes a first light source including at least one first light source to emit first light having a blue wavelength band, a second light source including at least one second light source to emit second light having a ultraviolet wavelength band, and a control unit to control the first light source and the second light source such that the second light source sequentially emits the second light after the first light source emits the first light. A dose of the second light source is less than 1/10 of a dose of the first light source.

Systems and methods for treating a cognitive disease or disorder are provided. A treatment method comprises: selecting a target volume of brain tissue to be stimulated; identifying at least one avoidance volume of brain tissue; selecting a first stimulation lead comprising at least one stimulation element; identifying at least one proposed trajectory for placement of the first stimulation lead based on the target volume and the at least one avoidance volume; placing the first stimulation lead along a placement trajectory selected from the at least one proposed trajectory; attaching the first stimulation lead to a stimulator; and stimulating the target volume with the first stimulation lead at least one stimulation element to treat at least one of a cognitive disease or a cognitive disorder. Systems include a stimulator with one or more stimulation leads and an image analyzer for identifying a proposed trajectory for placing the stimulation leads.

A method for treating a disease, disorder, or condition in a subject in need thereof, by administering either or both of (i) at least one photoactivatable pharmaceutical agent, or (ii) a first plurality of energy-emitting particles, into the subject in a region of the disease, disorder, or condition, whereby the administering is performed through inhalation; and applying an applied electromagnetic energy to the subject, wherein the applied electromagnetic energy directly or indirectly activates the at least one photoactivatable pharmaceutical agent, when present, and wherein when the first plurality of energy-emitting particles is present, the first plurality of energy-emitting particles absorbs the applied energy and emits an emitted electromagnetic energy, wherein the emitted electromagnetic energy interacts directly with the region of the disease, disorder, or condition or activates the at least one photoactivatable pharmaceutical agent.

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.