Dermatological systems and methods for providing a therapeutic laser treatment of tissue having poor chromophore selectivity using a laser source having a grating element to provide laser light having reduced linewidth. In some embodiments, the linewidth is reduced by at least half compared to the linewidth that would be provided in a system without the grating filter element. The linewidth may be reduced in some cases to 500 GHz or less, 300 GHz or less, or 200 Hz or less.

Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly illumination devices and related methods that may be used for intranasal delivery of irradiation are disclosed. Exemplary illumination devices may include a light guide that is optically coupled with a light source, where the light guide may be configured for insertion along one or more intranasal passageways. In this manner, the light guide may provide irradiation of light to tissues along or near the upper respiratory tract to prevent and/or treat various infections and other tissue conditions thereof. Light guides may include flexible materials with suitable dimensions and/or shapes that allow the light guides to follow variable paths of intranasal passageways during use.

The present invention relates to a radiation-emitting device (100), comprising at least one radiation source (110) configured to emit radiation of at least one wavelength towards a target (190) or towards a subject (192); at least one space or surface (140) configured to place the target (190) or the subject (192) therein or thereon; at least one means (185) configured to control the at last one radiation source's radiation emission towards the target (190) or towards the subject (192); wherein the radiation-emitting device (100) further comprises: at least one dual heating or cooling system (170) configured to heat or to cool the at least one space or surface (140) and comprising a Peltier device (171), said Peltier device (171) comprising at least two cuboids (172, 172′) made of two semiconductor materials having different electron densities, said at least two cuboids (172, 172′) being placed thermally in parallel to each other and electrically in series, interconnected with thermally conducting metal bridging plates (173, 173′) and sandwiched between a non-conducting material reduced temperature cover plate (174) and a non-conducting material elevated temperature cover plate (174′) and configured to be supplied with DC electric current via electrical connections (179); at least one first heat exchanger (175) thermally connected as a heat source to the Peltier device's (171) reduced temperature cover plate (174); at least one second heat exchanger (176) thermally connected as a heat sink to the Peltier device's (171) elevated temperature cover plate (174′); at least one fan or fan assembly (177, 178) configured to cause environmental air to flow along the at least one heat exchanger (175, 176); at least one nozzle (180) configured to pass and direct the environmental air flow having passed the at least one first and/or second heat exchanger (175, 176) and heated or cooled towards the at least one space or surface (140) configured to place the target (190) or the subject (192) therein or thereon; and at least one means (181) configured to control the DC electric current supply to the Peltier device (171). The invention also relates to a dual heating or cooling system, to the use of the dual heating or cooling system in a radiation-emitting device and a method of alternatingly heating or cooling areas or parts of a radiation-emitting device (100) before, during or after a radiation-emitting o

The inventors have developed a device for non-invasive treatment of diseases and conditions of living organisms (10) and a methodology for the use of plasma electrophysical stimulation coupled to resonance for the synchronous and synergistic application of several different physical stimuli, including light, electromagnetic field, electric current, dielectric barrier discharge, micro-vibrations and sound, which can operate at different cellular or tissue levels for the purpose of extended and more comprehensive stimulation of the target treated tissue. These factors are generated locally at the site of application, and the electromagnetic field along with electric currents allow a non-invasive application of stimulation by establishing a therapeutic resonant energy pathway (108) between the points of application of the device on the surface of the treated organism by affecting deeper located parts of the organism. In doing so, the resonance effects of these factors can be achieved by adjusting impulse profiles used for their generation. The present device also enables real-time monitoring of the treated tissue response, as well as dose control, and precise positioning of the impulse profile sources during treatment.

Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one virus. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 200 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided or which can be substantially harmful to cells of the body.

Exemplary system and method are provided for affecting nail growth rate, which can use a light dosage and a wavelength of light to affect a growth rate of a nail of a subject. For example, it is possible to detect a presence of a nail using, e.g., a presence detector. The nail can be irradiated over a treatment time with a light having a wavelength and a power, e.g., using a narrowband light source. Further, using a controller, it is possible to control one or more of the power and the treatment time to irradiate the nail with a light dosage that is within a biphasic light dosage range bounded by a lesser light dosage and a greater light dosage. The wavelength of the light and the light dosage can be configured to affect a growth rate of the nail.

Methods of treating a human subject exposed to radiation in space. The methods include the steps of administering to the subject in space a chlorophyll composition sufficient to provide at least about 0.15 μM of chlorophyll or its metabolites to the subject's bloodstream, and then exposing the subject in space to light having a wavelength of about 620 nm to about 760 nm and an intensity of about 5 W/m.sup.2 to about 1000 W/m.sup.2 for at least about 5 minutes. Methods for estimating the level of ubiquinol in the bloodstream of a subject having chlorophyll or chlorophyll metabolite in the bloodstream, which may be after treatment by the above methods, include the steps of exposing the subject's skin to light to induce fluorescence of the chlorophyll or chlorophyll metabolite, measuring the level of fluorescing chlorophyll or chlorophyll metabolite in the bloodstream using fluorescence spectroscopy, and correlating the level of fluorescing chlorophyll or chlorophyll metabolite to the level of ubiquinol using a predetermined scaling factor.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include eyeglasses, a photodiode positioned to detect ambient light, light sources, and an input device. The system can include a neural stimulation system that retrieves a profile and selects a light pattern having a fixed parameter and a variable parameter. The neural stimulation system can set a value of the variable parameter of the light pattern, construct an output signal, and then provide the output signal to the light sources to direct light towards the fovea.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

The present disclosure is directed to a phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems methods. In one embodiment a phototherapeutic apparatus can include a housing at least partially defining an irradiation zone, and an ultraviolet (UV) radiation source carried by the housing. The irradiation zone can be configured to accommodate at least a portion of a human patient. The phototherapeutic apparatus can further include a filter between the UV radiation source and the irradiation zone. The filter can be configured to at least substantially remove UV radiation outside of a predetermined spectrum centered at about 297 nm and having a bandwidth of at most 10 nm.