The invention relates to the radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject. In particular the invention relates to an endorectal probe device for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject. Furthermore the invention relates to an afterloading apparatus for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject using an endorectal probe device according to the invention. Moreover the invention relates to a method for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject, wherein the method implements the endorectal probe device according to the invention.

A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.

This disclosure provides design, material, preparation methods, and use alternatives for medical devices. An example method of preparing a stent comprises applying a coating to a portion of the stent at a medical treatment facility, the coating including a plurality of radioactive elements and a substrate. The plurality of radioactive elements are mixed with the substrate to form a mixture such that the plurality of radioactive elements are dispersed within the substrate prior to the coating being applied on the stent.

The present invention discloses an intracavitary radiotherapy apparatus, which is used for carrying radioactive particles or particle strips, comprising: a body that is formed by winding metal wires, and is a wire mesh having a hollow cavity penetrating through same in the forward and backward directions; and a radioactive particle groove that is provided on the outer surface of the body, is a cylindrical wire mesh having a hollow cavity penetrating through same in the forward and backward directions, and is used for accommodating the radioactive particles or particle strips. The radioactive particle groove comprises a plurality of groove bodies arranged in parallel, and the spacing between two adjacent groove bodies is less than the length of the radioactive particles or particle strips.

Disclosed are systems, devices, and methods for performing treatment along a lumen network, an exemplary method comprising receiving image data of a patient's lungs, mapping one or more luminal networks inside the patient's lungs based on the received image data, identifying a treatment target in the image data, determining a luminal pathway to the treatment target via at least one of the luminal networks, configuring treatment parameters for treatment of the treatment target and at least one of the luminal networks, navigating a tool inside at least one of the luminal networks to the treatment target, treating the treatment target with a primary treatment modality, and treating the luminal pathway of at least one of the luminal networks leading to or from the treatment target with a secondary treatment modality.

The present invention provides a system, a method, devices and a computer implemented with a method for the monitoring and the control of a subject's organ perfusion. The present invention further provides for the use of a system, a method, devices and a computer implemented with a method for the monitoring and the control of a subject's organ perfusion.

Systems and methods for minimally invasively delivering radiation therapy to a patient, e.g., with bladder cancer, is provided. The radiotherapy system includes one or more catheters that may be introduced to a patient's anatomical structure via a sheath using an intracavitary approach. The proximal end of the one or more catheters may be coupled to an afterloader for selectively delivering the radiation therapy, and the distal portion of the one or more catheters is transitionable between an uncoiled delivery state within the sheath and a coiled deployed state having a spherical configuration within the anatomical structure of the patient, such that the one or more catheters contacts at least a portion of the anatomical structure in the deployed state.

A method of treatment including: selecting tissue to be exposed to radiation for gradual closure of one or more blood vessel within the tissue to be exposed radiation; selecting radiation levels to promote gradual constriction of the one or more vessel; exposing the tissue to be exposed radiation to selected radiation levels.

A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a main catheter body. The main catheter body includes an outer catheter surface and an inner catheter surface that defines a longitudinally oriented lumen. The lumen extends between longitudinally spaced proximal and distal catheter face surfaces extending laterally between the inner and outer catheter surfaces. A sheath covers at least a portion of the outer catheter surface. The sheath includes a tapered portion protruding substantially longitudinally distally from a portion of the distal catheter face surface. A plurality of tubes extends through the lumen towards the distal catheter face surface. Each tube of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

A shield assembly for an intensity modulated brachytherapy (IMBT) system, has: a tubular applicator engageable to a rotating mechanism of the IMBT system, the tubular applicator having a peripheral wall enclosing an internal cavity extending longitudinally along a central axis; a radiation shield extending axially along the central axis and received within the internal cavity, the radiation shield made of an MRI-compatible and radiation attenuating material; and a radionuclide-receiving passage within the internal cavity of the tubular applicator, the radionuclide-receiving passage extending axially and being radially offset from the central axis.