An apparatus and methods for embolization of a patient includes vials for containing radiomicrospheres including inclined and domed base are described. Apparatus for delivering the microspheres from the vials to a patient for radioembolization are also described.

Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Methods and systems are described for a rotating shield brachytherapy device. As disclosed herein, the rotating shield brachytherapy (RSBT) apparatus may comprise a radiation source, a drive assembly, a catheter, and an applicator. The applicator can have an outer surface and opposed proximal and distal end portions and a longitudinal axis extending along a length of the catheter. The distal end portion of the catheter can comprise one or more radiation shields and is configured to receive the radiation source. The drive assembly can be configured to engage the proximal end portion of the catheter to selectively rotate the catheter about the longitudinal axis.

An apparatus and methods for embolization of a patient includes vials for containing radiomicrospheres including inclined and domed base are described. Apparatus for delivering the microspheres from the vials to a patient for radioembolization are also described.

Disclosed are systems, devices, and methods for performing treatment along a lumen network, an exemplary method comprising receiving image data of a patient's lungs, mapping one or more luminal networks inside the patient's lungs based on the received image data, identifying a treatment target in the image data, determining a luminal pathway to the treatment target via at least one of the luminal networks, configuring treatment parameters for treatment of the treatment target and at least one of the luminal networks, navigating a tool inside at least one of the luminal networks to the treatment target, treating the treatment target with a primary treatment modality, and treating the luminal pathway of at least one of the luminal networks leading to or from the treatment target with a secondary treatment modality.

A high crack pressure valve is described. The high crack pressure valve includes an inlet adapted to receive a medical fluid pressurized by a pump; an outlet in fluid communication with a fluid path element, wherein the fluid path element is in fluid communication with downstream system components of a fluid delivery system; and a moveable element having a crack pressure threshold. The moveable element has a first closed position and a second open position and is configured to move from the first closed position to the second open position when a fluid pressure at the inlet is greater than or equal to the crack pressure threshold. The pressure of fluid at the outlet of the high crack pressure valve has little or no effect on movement of the moveable element from the first closed position to the second open position. Fluid injector systems and fluid path elements which include the high crack pressure valve are also described.

Disclosed are systems, devices, and methods for performing treatment along a lumen network, an exemplary method comprising receiving image data of a patient's lungs, mapping one or more luminal networks inside the patient's lungs based on the received image data, identifying a treatment target in the image data, determining a luminal pathway to the treatment target via at least one of the luminal networks, configuring treatment parameters for treatment of the treatment target and at least one of the luminal networks, navigating a tool inside at least one of the luminal networks to the treatment target, treating the treatment target with a primary treatment modality, and treating the luminal pathway of at least one of the luminal networks leading to or from the treatment target with a secondary treatment modality.

The invention provides a device for treating tumors at a target site, the device having a first balloon containing a radio isotope; a second balloon encasing the first balloon wherein the second balloon includes structures to create a void between the first balloon and the second balloon; and a third balloon encasing the second balloon, wherein the third balloon facilitates removal of material from the target site. The invention also provides a method for treating a tumor excise site, the method simultaneously exposing the tumor to heat and radiation.

An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.

An intravascular device comprising: an expandable body having an expanded configuration and a contracted configuration, said expandable body in said expanded configuration having a convex curved shape having a base and walls; and a connector; wherein said connector is attached to said expandable body and recessed within said convex curved shape.