Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

A method and system may include a therapeutic agent having a radioactive source enclosed by a container. The container may be placed within a cavity of a medical device for treating animal tissue. The method and system allows a radioactive source to be manufactured in such a manner so as to control and spatially modulate the delivery of radiation doses to a treatment area of animal tissue, such as for tissue of humans. From the container, radiation doses and/or a radiation field are produced by the radiation source. The geometry and size of the radiation doses are controlled by the geometry of the container and the geometry of the radiation source as well as the type, number, and geometry of holes/slots in either the source material and/or a surface of the container.

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.

A brachytherapy treatment planning system includes a processor that: receives a planning image corresponding to at least a portion of a prostate; generates a brachytherapy treatment plan comprising, for each of a plurality of brachytherapy seeds or catheters, a corresponding brachytherapy seed or catheter position in the planning image such that the plurality of brachytherapy seed or catheter positions in the planning image together satisfy a desired radioactive dose objective in the prostate; receives a pre-treatment image corresponding to the at least a portion of a prostate; and maps each brachytherapy seed or catheter position in the planning image to a corresponding position in the pre-treatment image by performing a registration between the planning image and the pre-treatment image.

An intervention system employs an optical shape sensing tool (32) (e.g., a brachytherapy needle having embedded optical fiber(s) and a grid (50, 90) for guiding an insertion of the optical shape sensing tool (32) into an anatomical region relative to a grid coordinate system. The intervention system further employs a registration controller (74) for reconstructing a segment or an entirety of a shape of the optical shape sensing tool (32) relative to a needle coordinate system, and for registering the needle coordinate system to the grid coordinate system as a function of a reconstructed segment/entire shape of the optical shape sensing tool (32) relative to the grid (50, 90) (i.e., reconstruction of a segment/entire shape of the OSS needle inserted into/through the grid serving as a basis for the grid/needle coordinate system registration).

A mechanism facilitates the insertion of radioactive sources/source strands into soft tissue, such as breast tissue, that improves the reproducibility of the procedure and ensures that the sources are reliably and consistently inserted in an exact position per a patient prescription treatment plan from patient to patient as well as improve the ease-of-use of the device and procedure.

Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (.sup.165Ho) and dysprosium-164 (.sup.164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

Treatment of prostate cancer by regional and prolonged release of one or more nucleotide-based RNAi agents is provided.

Methods and systems for monitoring an automated radiopharmaceutical infusion apparatus are disclosed. A user interface graphically representing infusion apparatus components may be presented on a display device. Multiple sensors may be arranged within an infusion apparatus to measure property information associated with infusion apparatus components, including fluid pathways. The property information may include radioactivity and flow information. The property information may be compared with expected results. If the property information does not match the expected results, a fault condition may be indicated on the display device. The user interface may provide information and/or functions to manage the fault conditions.

The invention relates to a targeted seed implanting robot suitable for clinical human lithotomy position. The targeted seed implanting robot includes a rack, and further includes a position and posture adjusting mechanism, a contact force feedback friction wheel type targeted seed implant and a sine elastic amplification moment compensation mechanism; and the specific use steps are as follows: S1, driving; S2, meshing; S3, swing; S4, transverse movement; S5, compensation moment; S6, linear motion; S7, rotary motion; S8, detection; and S9, transmission of information. The sine elastic amplification moment compensation mechanism is adopted to realize the compensation of lower weight moment of any position shape of a big arm, reduce fluctuation of driving moment, improve stability of tail-end low-speed operation of the robot, combined with the position and posture adjusting mechanism, an external pin of an implant can adjust an incidence angle of the external pin in a fixed-point mode, and in addition, contact force feedback friction wheel type targeted seed implant installed at the tail end of the position and posture adjusting mechanism improves the force information perception ability in the targeted seed implanting process.