The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a toroidal shaped strontium radiological insert within an encapsulation. The encapsulation includes increased shielding in the center thereof.

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.

In the present disclosure, embodiments of flaring tip microcatheters, methods of deploying flaring tip microcatheters, and embolization treatment methods are disclosed. The flaring tip microcatheter may include a hollow shaft having a shaft lumen defined therein, a core disposed within the shaft lumen, and a tip comprising at least two petals affixed to a distal end of the core, the at least two petals comprising at least two wires wherein the core is hollow and defines a core lumen. The at least two wires may be configured to pull the at least two petals to form a flared configuration of the tip. The flared configuration of the tip may allow for laminar flow of a therapeutic agent distally from the tip.

Methods and systems for determination of flow parameters of administered fluid from a radioembolization delivery device may include translationally moving a device delivery arm of the radioembolization delivery device in a translational direction, wherein the device delivery arm is coupled to a syringe holder such that move in the translational direction one of proximally or distally advances the syringe holder; sensing, via one or more pattern sensors, a corresponding movement of a pattern associated with the translational device delivery arm movement as a sensed pattern movement; generating, via the one or more pattern sensors, one or more output signals based on the sensed pattern movement; and generating, via a processor, a flow rate of the administered fluid, a flow amount of the administered fluid, and/or the translational direction of movement of the device delivery arm with respect to the syringe holder based on the one or more output signals.

In the present disclosure, embodiments of microbead containment systems and containment methods are disclosed. The microbead containment system may include a microsphere container, which includes walls that define a containment space in the microsphere container, and microspheres within the containment space. The walls may include at least one magnetic component configured to produce a magnetic field within the containment space. The microspheres may include a diamagnetic material. The method of containing radioactive microspheres may include loading a plurality of microspheres comprising a diamagnetic material in a container comprising one or more magnetic components. The microspheres contained in the microsphere container interact with the magnetic field in a manner that prevents direct contact of the microspheres and the microsphere container.

A method for treating a tumor, comprising identifying a tumor as a breast cancer tumor and implanting in the tumor identified as a breast cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 9 MBq hour, per centimeter length.

The invention relates to a device for selective modification/destruction of organic tissue and to the use thereof for biomedical purposes, which includes a magnetic field generator (1) housed in a Faraday cage (6), with coils/conductors and a device for controlling the electrical intensity and voltage parameters of the terminals (7). Said generator consists of a device for generating chaotic magnetic fields ( ) coils/conductors having a geometric configuration (FIG. 1) which generates chaotic magnetic field lines, characterised topologically in space by chaotic field lines, which surround the magnetic field lines contained within a magnetic torus or KAM island (2), said structure being topologically controlled in space since it is contained within the Faraday cage (6). In addition, the invention also includes one or more devices generating polarised electromagnetic frequencies (infrared, microwave or X-ray) (3, 3.1, 3.2) with focussing capacity (4), coherence with the resonant frequency and polarisation in the direction of maximum absorbance of the nanoparticles/biomolecules oriented in the KAM island (2) which will submerge the target tissue for the selective modification or destruction. The device may operate at the X-ray frequency with or without the use of nanoparticles/biomolecules, in which case the destruction of the target tissue (4) occurs by controlling, in the direction of the paths, the secondary electrons and other charged particles produced by the X-ray beam, in the target tissue (4), by modulating the magnetic field intensity of the magnetic KAM island (2) in the target tissue (4), and the direction of incidence of the magnetic KAM island with respect to the X-ray beam in the target tissue (4).

A method and system may include a therapeutic agent having a radioactive source enclosed by a container. The container may be placed within a cavity of a medical device for treating animal tissue. The method and system allows a radioactive source to be manufactured in such a manner so as to control and spatially modulate the delivery of radiation doses to a treatment area of animal tissue, such as for tissue of humans. From the container, radiation doses and/or a radiation field are produced by the radiation source. The geometry and size of the radiation doses are controlled by the geometry of the container and the geometry of the radiation source as well as the type, number, and geometry of holes/slots in either the source material and/or a surface of the container.

Disclosed is a bore based medical system comprising a camera carrier configured to be mounted in the bore based medical system and configured to monitor and/or track patient motion within said bore based medical system during radiotherapy, the bore based medical system comprising a rotatable ring-gantry configured to emit a radiotherapy beam focused at an iso-center of the bore based medical system, wherein the ring-gantry is configured to rotate at least partly around a through-going bore having a front side and a back side, configured to receive from said front side, a movable couch configured to be moved into and out from the through-going bore, wherein further the through-going bore comprises an inner side facing an inside of the bore, and wherein the camera carrier is configured to be mounted inside the bore in connection with the inner side of the through-going bore.

A surgical implant is provided comprising a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.