A method for treating a cancerous tumor, by implanting in the cancerous tumor as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon of at least 10 Mega becquerel (MBq) hour, per centimeter length. Optionally, the sources are implanted in an array of sources, each source separated from its neighboring sources in the array by not more than 4.5 millimeters.

A method for treating a tumor, comprising identifying a tumor as a breast cancer or prostate cancer tumor and implanting in the tumor identified as a breast cancer or prostate cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 8 MBq hour, per centimeter length.

A method for treating a tumor, comprising identifying a tumor as a melanoma tumor and implanting in the tumor identified as a melanoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.4 Mega becquerel (MBq) hour and 8.6 MBq hour, per centimeter length.

Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.

The invention relates to a holder device for holding a medical instrument, the device comprising:

a base that is to be carried by an apparatus comprising a medical imaging probe associated with the medical instrument; and

a carrier structure for carrying the medical instrument and movably mounted on the base so as to be capable of moving on the base between a first position and a second position.

The invention also relates to an installation including both such a device and a needle-guide.

A surgical staple comprising a substrate and one or more coatings which slows the bioabsorption of the substrate. The coating can be selected so as to affect the environment surrounding the staple once the staple is implanted in the patient. The effect on the environment can cause the bioabsorption to occur within a desired time frame.

A system for assisting in performing an interventional procedure includes a first subsystem (1) and a second subsystem at different places, especially in different rooms. At a first place the first subsystem a) generates a first image of a subject (22) while an interventional device (12) is introduced into the subject and b) determines the position of the interventional device within the subject. At a second place the second subsystem a) generates a second image of the subject with the introduced interventional device and b) plans and/or monitors a treatment based on the second image and the already determined position of the interventional device, i.e. the second subsystem does not need to start a completely new position determination procedure, thereby reducing technical efforts. Moreover, the first and second images are generated by different imaging modalities which allows for, for instance, improved image guidance, planning and/or monitoring.

Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.

A system for dynamic localization of medical instruments includes an ultrasound imaging system (110) configured to image a volume where one or more medical instruments are deployed. A registration module (136) registers two images of the one or more medical instruments to compute a transform between the two images, the two images being separated in time. A planning module (142) is configured to have positions of the volume and the one or more medical instruments updated based on the transform and, in turn, update a treatment plan in accordance with the updated positions such that changes in the volume and positions of the one or more medical instruments are accounted for in the updated plan.

A surgical implant includes a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.