A polymeric radiation-source with customized geometries to maximize receipt of radiation into treatment areas that is formed from either radioisotopes molecularly bonded to a polymer or radioisotopes encased within a polymer.

Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and/or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.

The present invention relates to an ophthalmic treatment apparatus and a control method therefor, and provides an ophthalmic treatment apparatus and a control method therefor, the ophthalmic treatment apparatus comprising: a setting unit formed so as to set a treatment mode; a therapeutic light emission unit emitting therapeutic light at a target position of an eyeground multiple times so as to perform treatment; a monitoring unit for monitoring information on the state of the target position by the therapeutic light during the emission of the therapeutic light; and a control unit for determining whether a treatment intensity according to the treatment mode has been reached, by using the information monitored by the monitoring unit, and for controlling an operation of the therapeutic light emission unit on the basis of the determination.

A method comprises receiving one or more plan parameters of a first radiation treatment plan for a first patient and one or more passing rate data for the first treatment plan; generating a predictive model for passing rate data from the plan parameters of the first radiation treatment plan and the passing rate data for the first treatment plan; receiving one or more plan parameters of a second radiation treatment plan for a second patient; and applying the predictive model to the plan parameters of the second radiation treatment to generate one or more predicted passing rate data for the plan parameters for the second patient.

The invention relates to a device for supporting the testing of a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments.

The invention also relates to a method for testing of a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments.

Provided is a headset dosimeter for using a coulomb-stimulation device for breaking up iron-oxide mineralization with protein aggregation using a traversing ion beam comprising a head mounting part, a first stereoscopic block provided on one side to the head mounting part, and a second stereoscopic block provided at an opposite position to the first stereoscopic block based on the head mounting part, wherein each of the first stereoscopic block and the second stereoscopic block may include a mounting part capable of receiving at least one radiographic film.

Improved radiation therapy with field-in-field multi-leaf collimator, utilizing leaf sequencing Field-in-Field's (FIF) to accurately reproduce the input fluence map or original optimized dose distribution. The number of apertures used is constrained to a user-specified value all the way down to as few as 2 apertures which significantly magnifies the effect of poorly formed apertures. The disclosed invention further includes producing fluence maps with a homogenous dose throughout the treated volume utilizing leaf-sequencing Field-in-Field that reproduces more precise input fluence maps to yield optimized dose distribution.

Systems and methods are provided for generating surface brachytherapy applicators in which catheter channel trajectories are generated laterally from both sides of a cut plane bisecting an initial model of the surface brachytherapy applicator model, thereby mitigating the effects of patient-surface-induced curvature. The catheter channels may be defined based on catheter channel trajectories that are spatially distributed, relative to the cut plane, on both sides of the cut plane, and spatially offset relative to a patient-facing surface of the surface brachytherapy applicator model. In some example embodiments, catheter channel trajectories are spaced relative to the cut plane such that neighbouring catheter channel trajectories are evenly spaced along a set of contours. Prior to fabrication, the local radius of curvature of catheter channels may be adjusted in a manual or automated manner to exceed a threshold.

Cancer treatment methods using thermotherapy and/or enhanced immunotherapy are disclosed herein. One two-stage cancer treatment method comprises the steps of: (i) in a first stage, administering, to a patient with a metastatic malignancy, tumor-antibody-coated nanoparticles conjugated with one or more medications and/or one or more immune stimulators for attaching to circulating exosomes, extracellular vesicles, and/or circulating tumor cells, thus promoting a destruction of the circulating exosomes, extracellular vesicles, and/or circulating tumor cells by a cellular immune system of the patient; and (ii) in a second stage, treating a main tumor of the patient during the same session or during another session of therapy by administering the tumor-antibody-coated nanoparticles conjugated with the one or more medications and/or the one or more immune stimulators so as to stimulate the cellular immune response of the patient to destroy the main tumor.

Systems and methods for using surgical meshes to deliver chemotherapeutic agents and radioactive elements are presented herein. The surgical mesh may comprise multiple layers, with an inner or outer layer comprising the radioactive element, and an inner or outer layer comprising the chemotherapeutic layer. Upon exposure to physiological conditions, the surgical mesh along with pellets or powdered elements embedded therein biodegrades.