The invention relates to a planning apparatus for planning a radiation therapy. A medical image, in which a target to be irradiated is indicated, is reformatted based on ray geometries to be used during the radiation therapy to be planned, resulting in several reformatted medical images. Radiation therapy parameters being indicative of intensities of rays 5 to be used for irradiating a target 4 are determined based on the reformatted medical images by using a neural network unit. This allows to determine high quality radiation therapy parameters and hence allows for an improved planning of a radiation therapy. In particular, radiation and absorptions physics can be captured better, which can lead to the improved quality.

The present disclosure generally relates to an applicator for radiotherapy and a method for determining a thickness of a scattering foil and modulator therein. According to one embodiment, an applicator for radiotherapy may comprise a housing having a hollow structure with an opening, a scattering foil disposed at an opening of the hollow structure and configured to receive a first radiation and convert a portion of the first radiation into a second radiation while scattering the first radiation, and a modulator disposed inside the hollow structure and configured to modulate an intensity of mixed radiation including the first radiation and the second radiation.

Described herein are multi-leaf collimators that comprise leaf drive mechanisms. The leaf drive mechanisms can be used in binary multi-leaf collimators used in emission-guided radiation therapy. One variation of a multi-leaf collimator comprises a pneumatics-based leaf drive mechanism. Another variation of a multi-leaf collimator comprises a spring-based leaf drive mechanism having a spring resonator.

The invention relates a system for assisting in planning a radiation therapy treatment provided using a treatment plan comprising irradiation parameters for controlling a delivery of radiation. The system is configured to (i) receive a first dose distribution, (ii) obtain a first objective function, which depends upon at least one parameter and a dose distribution, (iii) determine a first value of the parameter such that the first objective function fulfills a predefined criterion when being evaluated for the first value of the parameter and for a second dose distribution derived from the first dose distribution, (iii) provide the first objective function in connection with the first value of the at least one parameter to a user for modifying the first objective function to generate a second objective function, and (v) determine the treatment plan using the second objective function. Further, the invention relates to a corresponding method and computer program.

A therapeutic apparatus may be provided. The therapeutic apparatus may include a magnetic resonance imaging (MRI) device configured to acquire MRI data with respect to a region of interest (ROI) and a radiation therapy device configured to apply therapeutic radiation to at least one portion of the ROI. The MRI device may include an annular cryostat having one or more chambers, an annular structure assembly and a recess disposed on the annular structure arrangement. The radiation therapy device may at least include an accelerator and one or more collimation components.

A method for controlled tumoricidal radiation dose delivery is disclosed. The method includes obtaining an image of a body organ; diving the image into a plurality of voxels; determining a set of feasible actions for the body organ by identifying an upper bound and a lower bound for the body organ; determining a utility function for the body organ; determining a disagreement point by identifying an ideal fluency map and a worst fluency map; determining a negotiation power weight based on a type of the body organ; and optimizing the plurality of radiation dose levels to the plurality of voxels based on the set of feasible actions, the utility function, the disagreement point, and the negotiation power weight. Other aspects, embodiments, and features are also claimed and described.

Disclosed herein are formulations and methods of administering formulations to starve cells of nutrients, such as amino acids. The formulations of the present invention can be substantially be devoid of one or more amino acid. The formulations of the present invention can be administered in a combination with an amino acid biosynthesis inhibitor or radiotherapy. A method disclosed herein can sensitize a cell to serine and/or glycine depletion.

An apparatus for use in a treatment planning process or in a treatment process, includes: an input for obtaining a parameter representing a number of beam on-off transitions; and a treatment planner configured to optimize a treatment plan based on parameter representing the number of beam on-off transitions. An apparatus includes: an input configured to obtain a width of a gating window for a treatment plan; and a gating window adjustor configured to adjust the width of the gating window during a treatment session. An apparatus includes: a dose calculator configured to calculate doses for different treatment variations; an evaluator configured to evaluate treatment acceptance criteria against the calculated doses; and a delivery limit module configured to determine one or more limits for one or more delivery parameters based on an evaluation of the treatment acceptance criteria by the evaluator.

In a radiation treatment plan that includes a plurality of treatment fields of multiple treatment modalities, such as IMRT modality and dynamic treatment path modality (e.g., VMAT and conformal arc therapy), an optimized spatial point sequence may be determined that optimizes the total treatment time, which includes both the beam-on time (i.e., during the delivery of radiation dose) and the beam-off time (i.e., during transitions between consecutive treatment fields). The result is a time-ordered field trajectory that intermixes and interleaves different treatment fields. In one embodiment, a dynamic treatment path may be cut into a plurality of sections, and one or more IMRT fields may be inserted between the plurality of sections.

Techniques for adjusting radiotherapy treatment for a patient in real time are provided. The techniques include retrieving a reference plan that includes three-dimensional (3D) volume representation of information for the patient and a plurality of radiotherapy beam delivery segments; identifying a first portion of the 3D volume representation of information for a first beam delivery segment of the plurality of radiotherapy beam delivery segments that includes a volumetric portion of a target irradiated by the first beam delivery segment; accessing a deformation model representing patient deformation during a radiotherapy treatment fraction; deforming the first portion of the 3D volume representation of information based on the deformation model; and updating one or more parameters of a radiotherapy treatment device based on the deformed first portion of the 3D volume representation of information.