There are described methods and systems for reconstructing a 3D anatomical structure undergoing non-rigid motion. The method comprises obtaining a 3D reference volume of the anatomical structure of the body, the reference volume corresponding to the anatomical structure at a reference phase of a respiratory cycle; acquiring 2D images of the anatomical structure at m prior times T.sub.in={t−m, . . . , t−2, t−1}; estimating a set of deformations of the 3D reference volume at times n future T.sub.out={t, t+1, . . . , t+n} from a previously learned probability distribution conditioned on partial observations and anatomical information; applying a spatial transformation to the 3D reference volume based on the set of deformations; and displaying the reference volume post-spatial transformation as a motion-compensated anatomical structure for each time step i ϵ T.sub.out.

Systems and methods are disclosed for treating back pain associated with a vertebral body of a patient. The system may include an external energy source configured to be positioned at a location external to the body of the patient, a linear configured to drive translation of the external source in one or more axes, a computer coupled to the external source and linear drive and programming executable on said computer for determining a target treatment site within or near the vertebral body based on acquired imaging data, positioning a focal point of the external energy source to substantially coincide with the target treatment site, and delivering a treatment dose of therapeutic energy at said target treatment site, wherein the treatment dose is configured to modulate a nerve within or near the vertebral body.

The present disclosure is related to systems and methods for radiation. The method may include obtaining a plurality of reference images of a target of a subject and reference physiological motion information of the subject. The plurality of reference images and the reference physiological motion information may be acquired in a radiation period. The method may include establishing a correlation model based on the plurality of reference images and the reference physiological motion information. The method may include monitoring real-time motion information of the target based on the correlation model during a radiation operation performed during the radiation period.

Systems, methods, and computer software relating to gating using non-parallel imaging planes, determining accumulated dose to tissues during radiotherapy with actual beam delivery information, stopping/adjusting/reoptimizing therapy based on such accumulated doses and the generation and use of prognostic motion models and prognostic-motion adapted radiation treatment plans are disclosed.

A tool for radiation therapy simulation or planning is disclosed which aids in avoiding collisions during treatment. Configurations of components including at least a radiation delivery device (30) and a patient (32) are generated. Each configuration defines positions of the components in a common coordinate system. For each configuration, proximities of pairs of components of the configuration are computed using ray tracing between three-dimensional surface models (30m, 32m, 36m, 38m) representing the components of the pair. A collision is identified as any pair of components having a computed proximity that is less than a margin for the pair of components. Each identified collision is displayed on a display (12), e.g. as a rendering. The simulations or planning may be used to verify deliverability of arc, 4Pi, or static therapy, to determine safety margins for collisions, to calculate and display realizable trajectories, and so forth.

A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.

The present disclosure relates to a cavity of a medical device. The cavity may include a bore and an accommodating cavity configured to provide an accommodating space for at least a portion of a couch in a radial direction of the bore. The accommodating cavity may be disposed on an inner wall of the bore and extend along an axial direction of the bore, and the accommodating cavity may be configured to form, with the bore, a connected space in which the at least a portion of the couch is allowed to move along an axial direction of the bore.

A novel method and a related system are configured to place measured trajectories into a voxel space, which moves with respect to a particle detector system. The trajectories are measured in a detector reference frame. The voxel space, typically fixed with respect to the object being imaged, is tracked optically with markers and a camera system. A decipherable correlation is established between a set of markers and a set of detector elements. This correlation provides coordinate transformation definitions to place the trajectories into the voxel space in medical imaging, treatment planning, and/or therapeutic applications. The novel method provides a clever process to register an optical tracking system with a particle detector system, which improves quality assurance, accuracy, speed, and operating cost efficiencies of ion, particle, and/or radiation-based imaging, treatment planning, or therapies. This novel method may be utilized in proton imaging, helium imaging, other ion-based imaging, or x-ray imaging.

A radiation therapy medical apparatus is disclosed. The medical apparatus comprises: a base; a cylindrical gantry, peripherally and rotatably supported by the base; a radiation therapy assembly, comprising an arm and a radiation head, wherein one end of the arm is fixed to a first position on a first side of the gantry and the other end thereof is extended outwardly, and the radiation head is fixed to the other end of the arm; an imaging assembly, mounted to a second side of the gantry opposite to the first side, and configured to be a first balanced weight part for balancing the radiation therapy assembly; and a counterbalance, fixed to the second side of the gantry, and configured to cooperate with the imaging assembly to prevent the gantry from turnover under action of the radiation therapy assembly and configured to dynamically balance with the radiation therapy assembly with respect to a rotation axis of the gantry.

The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.